“…Segmentation of individual MCs has been achieved by region growing, 6 grey-level thresholding on preprocessed regions of interest (ROIs), 5,7-12 morphologic operations, 3,[13][14][15] watershed algorithms, 16,17 Bayesian pixel classification combined with Markov random field models, 18 radial gradientbased methods, 17 and active contours. 19,20 Furthermore, the wavelet transform has been used for segmentation of MCs, due to its ability to spatially localize high-frequency components.…”