Invasive cystic hypersecretory carcinoma of the breast

Chitti, Srilata; Misra, Sunayana; Ahuja, Arvind; Gupta, Nikhil; Yelamanchi, Raghav

doi:10.4322/acr.2021.375

Cited by 1 publication

(5 citation statements)

References 14 publications

(59 reference statements)

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“…Guerry et al [7] elucidated the spectrum of these lesions in 1988. However, it is not part of the WHO classification (5th edition, 2019) due to the rarity of the tumour and lack of large studies on the biological behaviour and prognosis [2].…”

Section: Discussionmentioning

confidence: 99%

“…The age of onset of these tumours was found to be between 32 and 79 years, based on previous case reports with a mean age of 47 years [2]. The commonest clinical presentation was that of a significant palpable breast mass associated with pain.…”

Section: Discussionmentioning

confidence: 99%

“…The cyst, itself, is filled with amorphous, colloid-like material which may retract from the cyst wall resulting in scalloping of its margins. Occasionally, cyst rupture may cause spillage of the contents eliciting an inflammatory response in the surrounding stroma [2, 12].…”

Section: Discussionmentioning

confidence: 99%

“…The differential diagnosis of these tumours includes secretory carcinoma, micropapillary ductal carcinoma in situ, mucocele-like lesions, mucinous cystadenocarcinoma, and metastatic papillary thyroid carcinoma. They are all usually differentiated by the distinction in their gross and microscopic features and immunohistochemistry [2, 5]. The picture in core biopsy may be a confounding factor which makes clinical suspicion highly necessary for the diagnosis of such tumours.…”

Section: Discussionmentioning

confidence: 99%

“…Microscopically, the cysts are lined by pseudostratified epithelium with papillaroid folds or tufts [1]. Invasion is portended by the lining epithelium becoming poorly differentiated, losing the secretory property, and forming nests or nodules [2]. Herein, we report a case of invasive CHC with axillary metastasis.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Invasive Cystic Hypersecretory Ductal Carcinoma of Breast: Challenges in Diagnosis and Management

Alshaibani,

Chandramohan,

Khairi

et al. 2023

Case Rep Oncol

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Cystic hypersecretory lesions of the breast are a spectrum of conditions ranging from cystic hypersecretory hyperplasia with atypia and invasive cystic hypersecretory carcinoma (CHC). It is a subtype of ductal carcinoma of the breast. The tumour is very infrequent and hence, extensive literature is limited. This culminates in the fact that it does not feature as part of the WHO classification of breast tumours. However, a good knowledge about its distinct pathological features can avert misdiagnosis and help differentiate CHC from other conditions. Thus far, only 22 cases of invasive CHC have been reported, of which 3 were microinvasive. Only 7 cases of axillary lymph node metastasis have been documented. We report a case of invasive CHC of the breast that was metastatic to the axilla and refractory to neoadjuvant chemotherapy. Our case report aims to add to the literature on the disease, aiming to support large-scale studies in the future in order to elaborate on its clinical and biological characteristics.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%