Solid papillary carcinoma of the breast

Jadhav, Toyaja; Prasad, Shashi Shekhar; Guleria, Bhupesh; Tevatia, Manvir Singh; Guleria, Prerna

doi:10.4322/acr.2021.352

Cited by 2 publications

(5 citation statements)

References 19 publications

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“…The papillary carcinoma was subdivided into solid type and non-solid type, the positivity rate for solid type was 67% and for non-solid type was 8%. our findings are consistent with those of a previous study (26) wherein a significant level of chromogranin positivity was detected in solid papillary carcinoma of the breast. Former investigation (16) found that there was a significantly lower expression of chromogranin for benign papillary breast lesions than malignant papillary breast lesions (P=.05) which came in parallel to the result of our study.…”

Section: Discussionsupporting

confidence: 94%

Diagnostic Significance Of Immunohistochemistry in Papillary Breast Neoplasms

Bassyoni,

Elshawarby,

Abostate

2023

Benha Medical Journal

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Background: Papillary breast neoplasms are heterogenous group of breast diseases consisting of wide range of benign, atypical and malignant lesions. Evaluation of such papillary neoplasms is considered one of the most problematic issues in diagnosis of breast pathology depending on H&E only as they need different interventional treatment modalities. Aim of study: To differentiate papillary breast lesions depending on immunohistochemical staining of P63, SMA, CK14, chromogranin and ER. Materials and Methods: An Immunohistochemical study of P63, SMA, CK14, chromogranin and ER were conducted on 75 cases of different papillary breast neoplasms; papilloma (20 cases ) , DCIS ( 25 cases ) , solid papillary carcinoma ( 12 cases ), intracystic papillary carcinoma ( 11cases) and invasive micropapillary carcinoma (7 cases) . Results: Out of 75 cases, all cases of duct papillomas were positive to SMA, P63. Ninety percent (90 %) of them were positive to CK14 in comparison to malignant papillary: DCIS, intracystic papillary carcinomas. solid papillary carcinomas neoplasms which were negative (84.0%, 92.3 %, 90.0% & 100.0%, respectively). Ninety -two percentage (92 %) of DCIS cases, 92.3% intracystic papillary carcinomas, 90.0% solid papillary carcinomas and all cases of invasive micropapillary carcinomas-showed homogenous positivity for ER compared to papillomas that showed focal heterogenous expression with statistical significant (p<0.01). Solid papillary carcinoma cases were diffusely positive for chromgranin. P63 was more specific than SMA and CK14 in diagnosis of ductal papilloma (100% Specificity). chromogranin was more specific in discriminating solid papillary carcinoma (95.0% Specificity) .ER was the most sensitive marker in diagnosis of malignant papillary lesions (92.7 % sensitivity). Conclusion: A combined panel of markers consisting of P63, SMA, CK14, chromogranin and ER-could be helpful in differentiating begin, atypical and malignant papillary breast lesions which need different interventional treatment modalities. A wider scale study on different variants of malignant papillary lesions is recommended.

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Section: Discussionsupporting

confidence: 94%

Diagnostic Significance Of Immunohistochemistry in Papillary Breast Neoplasms

Bassyoni,

Elshawarby,

Abostate

2023

Benha Medical Journal

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“…Extracellular mucin production can also be seen. 4 Although Neuroendocrine differentiation has been reported in approximately half of all SPC cases in the current literature. 2,6 Not all SPC exhibit neuroendocrine differentiation.…”

Section: Discussionmentioning

confidence: 89%

“…9 The treatment protocols of SPC are still not well-established and vary from breast-conserving surgery to mastectomy depending upon the extent of the invasive component with or without adjuvant endocrine/chemotherapy. 4 In the case of our patient, neoadjuvant chemotherapy along with mastectomy was performed.…”

Section: Discussionmentioning

confidence: 93%

“…3 Most of these tumors show increased cellular proliferation with inconspicuous to absent papillary configuration. 4 SPC is an extremely rare breast tumor that is usually seen in postmenopausal women between 60 and 80 years of age. Our patient is post-menopausal and 74 years old.…”

Section: Discussionmentioning

confidence: 99%

“…Our patient is post-menopausal and 74 years old. [1][2][3][4][5][6] SPC originates from the ductal epithelium. The tumor size ranges from less than 10 to 150 mm.…”

Section: Discussionmentioning

confidence: 99%

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Invasive solid papillary breast carcinoma without neuroendocrine differentiation

Jayakumar,

Chauhan

2024

ACHR

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Solid papillary carcinoma (SPC) is considered a rare malignant breast tumor. This tumour can be either in situ or invasive .Both usually show excellent prognosis. Solid papillary carcinoma often shows neuroendocrine differentiation. 74-year-old lady an ulcerative retroareolar mass in the right breast. CECT Thorax revealed a large lobulated fungating ulceroproliferative mass lesion in the right breast with pectoral muscle involvement.without neuroendocrine differentiation. SPC with invasion is an uncommon variant of papillary carcinoma with frequent mucinous differentiation. Neuroendocrine differentiation although supports the diagnosis of solid papillary carcinoma may or may not be present.

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Solid papillary carcinoma of the breast

Cited by 2 publications

References 19 publications

Diagnostic Significance Of Immunohistochemistry in Papillary Breast Neoplasms

Diagnostic Significance Of Immunohistochemistry in Papillary Breast Neoplasms

Invasive solid papillary breast carcinoma without neuroendocrine differentiation

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