Mantle cell lymphoma presenting with lethal atraumatic splenic rupture

Eyerer, Frederick; Gardner, Juli-Anne; Devitt, Katherine

doi:10.4322/acr.2021.340

Cited by 2 publications

(1 citation statement)

References 30 publications

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“…B-cell hepatosplenic lymphoma (BCHSL) is strikingly rare, with only a handful of published cases 11. Splenic rupture is an unusual presenting sign of lymphoma—we only located 29 reported cases12–41 (online supplemental table 1). Given the rarity of BCHSL, it is not surprising that our case is the first report of this lymphoma presenting with splenic rupture and subsequently the Warburg effect.…”

Section: Introductionmentioning

confidence: 99%

B-cell hepatosplenic lymphoma presenting in adult patient after spontaneous splenic rupture followed by severe persistent hypoglycaemia: type B lactic acidosis and acute liver failure

Moen,

Hamilton-Dutoit,

Steiniche

et al. 2023

BMJ Case Rep

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A patient was admitted to hospital with splenic rupture, four 4 days after colonoscopy was performed following one month’s intermittent and aggravating abdominal pain. During recovery from splenectomy, the patient developed sudden tachycardic and tachypnoea. A blood sample revealed a very low blood glucose, high lactate and acidaemia.The patient required high-dose continuous intravenous glucose, while the lactate remained elevated. Decreasing consciousness with signs of acute liver failure necessitated transfer to an advanced intensive care unit. The patient’s clinical status rapidly deteriorated despite therapeutic intervention. The patient died of multiorgan failure eleven days post-splenectomy. Based on the pathology of the spleen and a post-mortem liver specimen, the patient was diagnosed with a primary extra-nodal B-cell hepatosplenic lymphoma (BCHSL) – an extremely rare form of non-Hodgkin lymphomanon.Splenic rupture followed by lactic acidosis and hypoglycaemia should lead to suspicion of a cancer-mediated Warburg effect, and prompt urgent chemotherapy.

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Section: Introductionmentioning

confidence: 99%

B-cell hepatosplenic lymphoma presenting in adult patient after spontaneous splenic rupture followed by severe persistent hypoglycaemia: type B lactic acidosis and acute liver failure

Moen,

Hamilton-Dutoit,

Steiniche

et al. 2023

BMJ Case Rep

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Mantle Cell Lymphoma With Non-traumatic Splenic Rupture Requiring Emergency Splenectomy

Plummer¹,

Yglesias²,

Swiger³

et al. 2022

Cureus

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Mantle cell lymphoma (MCL) is a type of non-Hodgkin (B-cell) lymphoma (NHL) with manifestations ranging from indolent to aggressive disease. This type of NHL is predominately found in western countries and affects men more often than women (M:F 2:1). The median age of diagnosis with the disease is around 60 years of age. In this report, the patient is a 68-year-old female who had an atraumatic splenic rupture with no past medical history of trauma. She presented to the emergency department with severe abdominal pain in her left upper quadrant. An emergency splenectomy was executed successfully, and the patient was stabilized. In this case report, we will discuss the pathogenesis, clinical presentation, known clinical treatment, diagnostic testing, and atraumatic splenic rupture.

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Mantle cell lymphoma presenting with lethal atraumatic splenic rupture

Cited by 2 publications

References 30 publications

B-cell hepatosplenic lymphoma presenting in adult patient after spontaneous splenic rupture followed by severe persistent hypoglycaemia: type B lactic acidosis and acute liver failure

B-cell hepatosplenic lymphoma presenting in adult patient after spontaneous splenic rupture followed by severe persistent hypoglycaemia: type B lactic acidosis and acute liver failure

Mantle Cell Lymphoma With Non-traumatic Splenic Rupture Requiring Emergency Splenectomy

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