The vasa vasorum of the large pulmonary vessels are involved in COVID-19

Daisley, H; Rampersad, Arlene; Daisley, Martina; Ramdin, Amit; Acco, Oneka; Narinesingh, Farhaana; Humphrey, Ornella; James, E Baumgartner

doi:10.4322/acr.2021.304

Cited by 4 publications

(3 citation statements)

References 6 publications

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“…Many parallels were drawn between TA‐TMA after HSCT and systemic TMA from COVID in non‐HSCT patients. Autopsy cases from COVID patients demonstrated C5b‐9 and C4d deposits in a pattern and severity similar to reports in TA‐TMA after HSCT 106–108 . Complement effector functions that lead to SARS‐CoV‐2‐induced TMA and acute lung injury are well‐described.…”

Section: Additional Considerations For Ta‐tma Therapy and Complement ...supporting

confidence: 71%

“…Autopsy cases from COVID patients demonstrated C5b-9 and C4d deposits in a pattern and severity similar to reports in TA-TMA after HSCT. [106][107][108] Complement effector functions that lead to SARS-CoV- With novel cellular therapies like chimeric antigen receptor T-cells (CARTs) and VSTs on the rise, we are bound to induce cytokine storms with the potential to injure the endothelium in different organs. 94 While cellular therapy-induced cytokine release syndrome (CRS) may respond to IL-6 blockade, more complicated syndromes like immune effector cell-associated neurotoxicity syndrome (ICANS) do not have effective interventions.…”

Section: C5 and Lectin Pathway Inhibitorsmentioning

confidence: 99%

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Reeling in complement in transplant‐associated thrombotic microangiopathy: You're going to need a bigger boat

Jodele

Sabulski

2023

American J Hematol

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Over the last decade there have been numerous advances in both the diagnosis and treatment of transplant-associated thrombotic microangiopathy (TA-TMA). These are largely the result of an improved understanding of complement activation in TA-TMA and the ability to prevent end organ injury and death with timely initiation of complementblocking therapies. In this article, we review our current understanding of the pathophysiology of TA-TMA, particularly as it pertains to complement activation, endothelial injury, and clinical management. We then review novel complement-blocking therapies that are currently under investigation for use in TA-TMA, as well as discuss special considerations for complement-blocking therapy in hematopoietic stem cell transplant recipients. Through these reviews we aim to answer or at least provide an educated discussion on the most commonly posed TA-TMA management questions and dilemmas.

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Section: Additional Considerations For Ta‐tma Therapy and Complement ...supporting

confidence: 71%

Section: C5 and Lectin Pathway Inhibitorsmentioning

confidence: 99%

Reeling in complement in transplant‐associated thrombotic microangiopathy: You're going to need a bigger boat

Jodele

Sabulski

2023

American J Hematol

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“…The recent data about the worsening of the course of atherosclerosis in patients with COVID-19 infection, the presence of inflammation of arterial wall both in COVID-19 and atherosclerosis, the reports of higher frequencies of cardiovascular complications in COVID-19 and post-COVID-19 disorders, and the importance of Vasa vasorum in atherogenesis all call for the investigation of pathomorphology of vessel walls in these diseases [ 7 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

COVID-19 and Vasa vasorum: New Atherogenic Factor? A Case Report and Autopsy Findings

et al. 2023

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Patients with COVID-19 demonstrate higher rates of cardiovascular complications, including thromboses and thromboembolism. One may suppose that the action of SARS-CoV-2 transforms stable atherosclerotic plaques into unstable status. Cardiovascular complications in COVID-19 may be caused by progressive viral alteration of the blood vessels, including Vasa vasorum. A lethal case of ischemic brain disease caused by cerebral atherosclerosis and exacerbated by a stroke during COVID-19 infection is briefly described. The results of the autopsy showed perivascular lymphocytic infiltration and signs of Vasa vasorum vasculitis with thrombi of adventitial microvasculature. The data discussed in the article are interpreted in the context of the concept giving the important role in atherogenesis to Vasa vasorum.

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On vasa vasorum: A history of advances in understanding the vessels of vessels

Phillippi

2022

Sci. Adv.

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The vasa vasorum are a vital microvascular network supporting the outer wall of larger blood vessels. Although these dynamic microvessels have been studied for centuries, the importance and impact of their functions in vascular health and disease are not yet fully realized. There is now rich knowledge regarding what local progenitor cell populations comprise and cohabitate with the vasa vasorum and how they might contribute to physiological and pathological changes in the network or its expansion via angiogenesis or vasculogenesis. Evidence of whether vasa vasorum remodeling incites or governs disease progression or is a consequence of cardiovascular pathologies remains limited. Recent advances in vasa vasorum imaging for understanding cardiovascular disease severity and pathophysiology open the door for theranostic opportunities. Approaches that strive to control angiogenesis and vasculogenesis potentiate mitigation of vasa vasorum–mediated contributions to cardiovascular diseases and emerging diseases involving the microcirculation.

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The vasa vasorum of the large pulmonary vessels are involved in COVID-19

Cited by 4 publications

References 6 publications

Reeling in complement in transplant‐associated thrombotic microangiopathy: You're going to need a bigger boat

Reeling in complement in transplant‐associated thrombotic microangiopathy: You're going to need a bigger boat

COVID-19 and Vasa vasorum: New Atherogenic Factor? A Case Report and Autopsy Findings

On vasa vasorum: A history of advances in understanding the vessels of vessels

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