This research investigated the possible relationships between the Use of Information Systems, Organizational Memory Health, and Organizational Attention. Qualitative and quantitative research techniques were used to achieve its achievement. In the qualitative research, conducted through interviews with managers of Brazilian and Portuguese companies, we sought to identify elements of Organizational Memory in their day-to-day life. The data collected in the interviews were treated with the Content Analysis technique. The qualitative part of the research indicates that organizational attention is directly linked to innovation processes and the use of Information Systems, being essential elements in decision making. The qualitative part also served as the basis for the creation of the statements of the electronic questionnaire related to organizational Attention. In the quantitative part of the research, data were collected via an electronic questionnaire sent to Brazilian and Portuguese companies, which were treated with the structural equation modeling technique. The results of the quantitative part pointed to the relevance of the Use of Information Systems in The Health of Organizational Memory, and the latter, for Organizational Attention, in Brazilian and Portuguese companies. It was also possible to verify that the results resulting from the use of information systems occurred significantly, emphasizing the Effectiveness of Decisions and the Consistency of Organizational Identity. One point that still deserves further deepening is evaluating the contribution of the use of Information Systems on Organizational Attention since, although positive, the relationship between them was not significant. The research also opens possibilities for its application in other countries to compare the results and practices adopted by distinct cultures.