Efeito de um programa de exercício físico moderado em ratos de diferentes modelos de obesidade

Gomes, Rodrigo Mello; Marques, Angélica Sbrolini; Torrezan, Rosana; Scomparin, Dionízia Xavier; Mathias, Paulo Cézar de Freitas; Rinaldi, Wilson

doi:10.4025/reveducfis.v23i2.13242

Cited by 2 publications

(6 citation statements)

References 26 publications

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“…Taken together, these small differences resulted in a mean AUC statistically smaller in group SS. Larger AUCs in rats from small litters are a more common finding (42), but not always (20). In this study, the GTT values are consistent with the biometric data discussed above, and do not indicate overt changes in glucose tolerance in the female SS rats.…”

Section: Discussionsupporting

confidence: 89%

“…; Novolin; Novo Nordisk, Montes Claros, MG, Brazil) for the experiments of insulin tolerance. Blood samples were collected from a caudal incision at 0, 5,10,15,20,25,30,45,60,90, and 120 min, 0 min being immediately before insulin injection. Blood glucose was determined with test strips and glucose meter and expressed as mg·dL ) was calculated for the first 30 min of the test (31).…”

Section: Insulin Tolerance Testmentioning

confidence: 99%

“…Life quality and expectancy are affected by excessive body fat. Insulin resistance, cardiovascular diseases, diabetes, and hypercholesterolemia are some examples of the susceptibility to metabolic and chronicdegenerative impairments that follow obesity (7,20,36,42).…”

Section: Introductionmentioning

confidence: 99%

“…Exercise, regardless of body weight loss, contributes to the preservation of the lean mass, appetite control, improvement of physical condition, increase of the resting metabolic rate, and has a positive interference on the individual's health (20,24,33,39). Ciolac and Guimarães (8) state that an active life can prevent obesity, regardless of the kind of physical activity.…”

Section: Introductionmentioning

confidence: 99%

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Treadmill walking differently affects body composition and metabolic parameters of female rats from normal or small litters

et al. 2016

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This work assessed whether walking affects bodily development and metabolic parameters of female rats raised in small litters (three pups, group S) or control litters (nine pups, group C). After weaning, some of the rats had five sessions per week of a 30-min treadmill walking (CE and SE), while the others remained sedentary (CS and SS) until the age of 120 days. Exercise caused a reduction of body weight (CS/CE = 1.18), Lee index (CS/CE = 1.04), fasting blood glucose (CS/CE = 1.35), mesenteric (CS/CE = 1.23), and ovarian fat (CS/CE = 1.33) in CE, but only glucose was decreased in SE (SS/SE = 1.16). The diameter of adipocytes decreased to a half in the small-litter groups. Exercise increased subcutaneous (CS/CE = 0.88 and SS/SE = 0.71), but decreased retroperitoneal adipocytes (CS/ CE = 1.2 and SS/SE = 1.3). Litter size reduction had little impact on females at the age of 120 days, but the light physical activity seemed insufficient to counteract all the effects of lactational overfeeding. On the other hand, pups from exercised mothers had a decrease in their biometric and glycemic indexes, demonstrating the transgenerational action of regular, although light, exercise.

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Section: Discussionsupporting

confidence: 89%

Section: Insulin Tolerance Testmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Treadmill walking differently affects body composition and metabolic parameters of female rats from normal or small litters

et al. 2016

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“…This confirms dietary efficiency, as it is rich in lipids and/or carbohydrates. 12,[19][20][21] However, to date, no reports are available in the literature concerning the effects of the interaction between the sucrose-and lipid-rich diet applied in this study and physical treadmill training before pregnancy.…”

Section: Dietary and Physical Training Effects On The F0 Generationmentioning

confidence: 98%

Multigenerational effects of chronic maternal exposure to a high sugar/fat diet and physical training

Terra

Fontoura

Nogueira

et al. 2019

J Dev Orig Health Dis

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Pregnant individuals who overeat are more likely to predispose their fetus to the development of metabolic disorders in adulthood. Physical training is a prevention and treatment interventional strategy that could treat these disorders, since it improves metabolism and body composition. This study assessed the protective effect of physical exercise against possible metabolic changes in generations F1 and F2, whose mothers were subjected to a high-sugar/high-fat (HS/HF) diet. Wistar rats belonging to generation F0 were distributed into four groups (n = 10): sedentary control (CSed), exercised control (CExe), sedentary HS/HF diet (DHSed) and exercised HS/HF diet (DHExe). From 21 to 120 days of age, maintained during pregnancy and lactation period, CSed/CExe animals received standard feed and DHSed/DHExe animals a HS/HF diet. Animals from the CExe/DHExe underwent physical training from 21 to 120 days of age. Male and female F1 and F2 received a normocaloric feed and did not perform any physical training, categorized into four groups (n = 10) according to the maternal group to which they belonged to. An increase in body weight, adiposity and glucose, and a change in lipid profile in F0 were observed, while exercise reduced the biochemical parameters comparing DHSed with DHExe. Maternal exercise had an effect on future generations, reducing adiposity, glucose and triglyceride concentrations, and preventing deleterious effects on glucose tolerance. Maternal overeating increased health risks both for mother and offspring, demonstrating that an HS/HF diet intake promotes metabolic alterations in the offspring. Importantly, the physical training performed by F0 proved to be protective against such effects.

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Efeito de um programa de exercício físico moderado em ratos de diferentes modelos de obesidade

Cited by 2 publications

References 26 publications

Treadmill walking differently affects body composition and metabolic parameters of female rats from normal or small litters

Treadmill walking differently affects body composition and metabolic parameters of female rats from normal or small litters

Multigenerational effects of chronic maternal exposure to a high sugar/fat diet and physical training

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