Effects of different sources of selenium supplementation on antioxidant indices, biochemical parameters, thyroid hormones and Se status in transition cows

Khalili, Mohsen; Chamani, Mohammad; Amanlou, H.; Nikkhah, Ali; Sadeghi, Ali Asghar

doi:10.4025/actascianimsci.v41i1.44392

Cited by 9 publications

(10 citation statements)

References 25 publications

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“…Similar results were detected previously in Jersey cows supplemented with Se-yeast during the last eight weeks of gestation [14] and in Holstein cows supplemented with selenomethionine from 21 days prepartum to 21 days post-partum [41] or inorganic Se + vitamin E [42].…”

Section: Selenium Bioforti Ed Hay Improves Albumin Production By the supporting

confidence: 89%

“…To further complicate the interpretation of the urea data, an increase in blood urea concentration in Se supplemented animals was also observed in rats supplemented with inorganic Se [48] and in one year old Angus steers fed organic Se [49] but not in multiparous dairy cows [41,50]. Thus, it is possible that the observed increased circulating urea by feeding Se-bioforti ed hay might only be associated with the young age of the cows used.…”

Section: Selenium Bioforti Ed Hay Improves Albumin Production By the mentioning

confidence: 99%

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Selenium Biofortified Alfalfa Hay Supplemented to Dairy Heifers During the Peripartum Affects the Antioxidant Function of Albumin but Has Little Impact on Metabolic and Immune Function

Jaaf¹,

Mezzetti²,

Trevisi³

et al. 2020

Preprint

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Background: the peripartum is the most critical period in dairy cows with high incidence of diseases due to immune dysfunctions, often paired with systemic inflammation and oxidative stress. Selenium is a trace mineral that plays an important role in anti-oxidative function and immune response. We hypothesize that supplementing dairy cows with a relatively small amount of Se-biofortified hay during the last 40 days of pregnancy and early lactation improves performance, metabolism, oxidative status, and immune response.Methods: ten Jersey and 8 Holstein pregnant dairy heifers were divided into two groups and supplemented with 1 kg/100 kg BW of Se-biofortified (Sel; n=9; 3.2 ppm Se) or non-biofortified (Ctr; n=9; 0.4 ppm Se) alfalfa hay from 40 days prior- to 2 weeks post-partum. Heifers were monitored daily for feed intake, activity, and milk yield, and weekly for BW and BCS. Milk samples were assessed for components and fatty acid profile. Blood samples were collected regularly to assess metabolic, oxidative, and inflammatory biomarkers, and to evaluate leukocytes phagocytosis and differential through flow cytometry.Results: supplementation of Se biofortified hay did not affect feed intake, milk yield, BW, BCS, milk components, and any of the parameters measured on leukocytes but increased the hematocrit. Animal receiving Se biofortified hay had larger concentration of plasma albumin and a tendency for larger blood urea, indicating a possible better liver status, especially post-partum. None of the parameters measured in plasma related to the oxidative status were affected, except the concentration of advanced oxidation protein products that was greater in Sel vs. Ctr. The concentration of advanced oxidation protein products was negatively correlated with parameters related to inflammation but positively associated to plasma albumin suggesting a possible improved anti-oxidative function of circulating albumin by Se-biofortified hay supplementation.Conclusions: feeding Se-biofortified hay during pregnancy in dairy heifers had little effect on metabolic, inflammatory, and oxidative status parameters with no effect on performance or immune response. Supplementation with Se-biofortified hay increased plasma level of albumin, possibly as consequence of improved liver function, promoting the antioxidant role of albumin as indicated by increased AOPP.

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Section: Selenium Bioforti Ed Hay Improves Albumin Production By the supporting

confidence: 89%

Section: Selenium Bioforti Ed Hay Improves Albumin Production By the mentioning

confidence: 99%

Selenium Biofortified Alfalfa Hay Supplemented to Dairy Heifers During the Peripartum Affects the Antioxidant Function of Albumin but Has Little Impact on Metabolic and Immune Function

Jaaf¹,

Mezzetti²,

Trevisi³

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Next to this, several observational patient studies showed a positive correlation between Se and albumin levels [ 42 , 43 ], which was substantiated by in vivo evidence showing that Se supplementation increased albumin concentration [ 44 ]. However, residual confounding or a reverse association (i.e., low albumin leads to low Se levels) cannot be excluded, as approximately 10% of the total serum Se binds to albumin [ 42 ].…”

Section: Discussionmentioning

confidence: 88%

A Clinical Tool to Predict Low Serum Selenium in Patients with Worsening Heart Failure

Al‐Mubarak

Beverborg

Anker³

et al. 2020

Nutrients

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Selenium is an essential micronutrient, and a low selenium concentration (<100 µg/L) is associated with a poorer quality of life and exercise capacity, and an impaired prognosis in patients with worsening heart failure. Measuring selenium concentrations routinely is laborious and costly, and although its clinical utility is yet to be proven, an easy implemented model to predict selenium status is desirable. A stepwise multivariable logistic regression analysis was performed using routinely measured clinical factors. Low selenium was independently predicted by: older age, lower serum albumin, higher N-terminal pro-B-type natriuretic peptide levels, worse kidney function, and the presence of orthopnea and iron deficiency. A 10-points risk-model was developed, and a score of ≥6 points identified >80% of patients with low selenium (sensitivity of 44%, specificity of 80%). Given that selenium and iron overlap in their physiological roles, we evaluated the shared determinants and prognostic associates. Both deficiencies shared similar clinical characteristics, including the model risk factors and, in addition, a low protein intake and high levels of C-reactive protein. Low selenium was associated with a similar or worse prognosis compared to iron deficiency. In conclusion, although it is difficult to exclude low selenium based on clinical characteristics alone, we provide a prediction tool which identifies heart failure patients at higher risk of having a low selenium status.

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“…Another study showed that supplemental SM resulted in higher GPx1 and superoxide dismutase activities and increased plasma Se compared to SS (Sun et al 2019). However, in a more recent study, although Se plasma levels were increased more in cows fed Se-yeast and SM compared to those fed SS, no effects on biochemical antioxidant parameters were observed (Khalili 2019).…”

Section: Discussionmentioning

confidence: 90%

Biochemical and molecular assessment of selenium forms for the alleviation of oxidative stress in senescent human fibroblasts

Ghneim¹,

Alfhili²,

Alharbi³

et al. 2022

gpb

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Selenium enhances the cellular antioxidant capacity and alleviates oxidative stress. We investigated the transcriptional and enzymatic activities of selenium-dependent glutathione peroxidase 1 and thioredoxin reductase 1 (TrxR1), and levels of glutathione, hydrogen peroxide, lipid peroxides, and protein carbonyls in primary passage 5 (P5) and senescent passage 25 (P25) and 30 (P30) fibroblasts. Cells were incubated in either standard Dulbecco growth medium (CM1) containing normal plasma selenium levels (0.8 μmol/l), or in CM2, CM3, and CM4 containing 3 μmol/l (5 μmol/l for TrxR1) sodium selenite, L-hydroxyselenomethionine, or Se-methylselenocysteine, respectively. Gene transcripts and activities of both investigated enzymes as well as the levels of reduced glutathione were significantly increased in CM2-, CM3-, and CM4-incubated senescent P25 and P35 cells compared against those incubated in CM1. In congruence, although all oxidative stress parameters including oxidized glutathione were significantly lower in CM2-, CM3-, and CM4-incubated senescent cells compared against those incubated in CM1, such reductions were of significantly higher magnitude in CM3 and CM4 cells compared against those in CM2. In conclusion, organic L-hydroxyselenomethionine and Se-methylselenocysteine are equally more potent at alleviating oxidative stress in senescent cells than inorganic sodium selenite, and thus could be beneficial for use in elderly subjects and those with oxidative stress-associated disease.

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Effects of different sources of selenium supplementation on antioxidant indices, biochemical parameters, thyroid hormones and Se status in transition cows

Cited by 9 publications

References 25 publications

Selenium Biofortified Alfalfa Hay Supplemented to Dairy Heifers During the Peripartum Affects the Antioxidant Function of Albumin but Has Little Impact on Metabolic and Immune Function

Selenium Biofortified Alfalfa Hay Supplemented to Dairy Heifers During the Peripartum Affects the Antioxidant Function of Albumin but Has Little Impact on Metabolic and Immune Function

A Clinical Tool to Predict Low Serum Selenium in Patients with Worsening Heart Failure

Biochemical and molecular assessment of selenium forms for the alleviation of oxidative stress in senescent human fibroblasts

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