Open field behavior and intra-nucleus accumbens dopamine release in vivo in virgin and lactating rats.

Habr, Soraya Ferreira; Bernardi, Maria Martha; Conceição, Isaltino Marcelo; Freitas, Thalma Ariani; Felício, Luciano Freitas

doi:10.3922/j.psns.2011.1.013

Cited by 9 publications

(5 citation statements)

References 51 publications

(66 reference statements)

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“…Our findings corroborate the previous reports suggesting that ovariectomy affects significantly the cognitive processes [ 10 , 18 , 19 ]. The decrease in line crossing (indicator of rodent natural drive to explore a novel environment) and rearing episodes numbers (assessment of the presence of potential environmental dangers) observed in ovariectomized rats in this study also indicate cognitive impairment [ 20 , 21 ], as well as mood affections [ 22 ]. Decreases in the time spent in the center of the open field arena, a well-established indicator of anxiety in rodents [ 22 – 25 ], also suggested an increased anxiety in ovariectomized rats in this study.…”

Section: Discussionmentioning

confidence: 94%

Memory and exploratory behavior impairment in ovariectomized Wistar rats

et al. 2018

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BackgroundEstrogen deficiency is linked to changes in several physiological processes, but the extent to which it associates with cognitive changes in menopause context is controversial.RationaleWe evaluated the impact of ovariectomy on memory processes and normal exploratory behavior in Wistar rats.MethodsYoung adult rats (4–6 months) were either ovariectomized (OVX group) (N = 10), sham operated (N = 10), or untouched (naïve controls) (N = 8). Afterwards, they were monitored for 12 weeks during which their cognitive functions were evaluated at first week (S1), second (S2), every 3 weeks (S5, S8) and then at week 12 (S12) using: (i) object recognition test to evaluate the short-term and long-term non-spatial memory; (ii) the object placement test to assess the spatial memory; and (iii) normal exploratory behavior components like locomotor and vertical activities in an open field arena.ResultsMarked changes in ovariectomized rats were observed in long-term non-spatial memory (~ 40% change vs. naïve and sham, P < 0.001) and spatial memory (~ 30% change, P < 0.05) from S2. Instead, from S5 the exploratory behavior was affected, with decreases in line crossing and rearing episode numbers (~ 40% change, P < 0.01), and in the time spent in the center of open field arena (~ 60% change, P < 0.01).ConclusionsOur findings support the involvement of sex hormones in cognitive functions in female rats and suggest that controversy on the importance of cognitive affections in menopause context may emerge from differences between short-term and long-term memory processes.

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Section: Discussionmentioning

confidence: 94%

Memory and exploratory behavior impairment in ovariectomized Wistar rats

et al. 2018

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“…For example, evaluation of anxiety-like behavior between postpartum and virgin mice and rats in the anxiety-like light–dark test revealed no differences, 66 while locomotion was reduced in lactating rats when compared to virgin ones. 67 Further, when isolated from pups, lactating wild-type C57BL6/J mice were found to be more anxious in marble burying behavior. 19 It is interesting to note that though lactating females were more anxiety-like, locomotor activity among vehicle treated lactating, non-lactating, and nulliparous compulsive-like females were not different, which supports that the anxiety-like differences were not due to activity level differences.…”

Section: Resultsmentioning

confidence: 98%

“…However, the component of emotionality can be perceived very differently by lactating females as evaluated through behavioral tests. For example, evaluation of anxiety-like behavior between postpartum and virgin mice and rats in the anxiety-like light–dark test revealed no differences, while locomotion was reduced in lactating rats when compared to virgin ones . Further, when isolated from pups, lactating wild-type C57BL6/J mice were found to be more anxious in marble burying behavior .…”

Section: Results and Discussionmentioning

confidence: 99%

Postpartum Lactation-Mediated Behavioral Outcomes and Drug Responses in a Spontaneous Mouse Model of Obsessive–Compulsive Disorder

Mitra

Mucha

Owen

et al. 2017

ACS Chem. Neurosci.

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Using a spontaneous mouse model of obsessive-compulsive disorder (OCD), the current study evaluated the influence of postpartum lactation on the expression of compulsive-like behaviors, SSRI effectiveness, and the putative role of oxytocin and dopamine in mediating these lactation specific behavioral outcomes. Compulsive-like lactating mice were less compulsive-like in nest building and marble burying and showed enhanced responsiveness to fluoxetine (50 mg/kg) in comparison to compulsive-like nonlactating and nulliparous females. Lactating mice exhibited more anxiety-like behavior in the open field test compared to the nulliparous females, while chronic fluoxetine reduced anxiety-like behaviors. Blocking the oxytocin receptor with L368-899 (5 mg/kg) in the lactating mice exacerbated the compulsive-like and depression-like behaviors. The dopamine D2 receptor (D2R) agonist bromocriptine (10 mg/kg) suppressed marble burying, nest building, and central entries in the open field, but because it also suppressed overall locomotion in the open field, activation of the D2R receptor may have inhibited overall activity nonspecifically. Lactation- and fluoxetine-mediated behavioral outcomes in compulsive-like mice, therefore, appear to be partly regulated by oxytocinergic mechanisms. Serotonin immunoreactivity and serum levels were higher in lactating compulsive-like mice compared to nonlactating and nulliparous compulsive-like females. Together, these results suggest behavioral modulation, serotonergic alterations, and changes in SSRI effectiveness during lactation in compulsive-like mice. This warrants further investigation of postpartum events in OCD patients.

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“…Open Field Test (OFT): This test is commonly used to assess spontaneous motor activity and anxiety ( Habr, Bernardi, Conceição, Freitas, & Felicio, 2011 ). For OFT, a square black open field arena (33 × 33 × 33 cm) was used.…”

Section: Methodsmentioning

confidence: 99%

Effects of N-acetylcysteine on Noise Exposure-induced Oxidative Stress and Depressive- and Anxiety-like Behaviors in Adult Male Mice

Mahmoodzadeh

Mahmoudi

Gorgani‐Firuzjaee

et al. 2021

BCN

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Background: Depression and anxiety are the most common psychiatric disorders that widely occur in industrial societies and severely affect individual's lives. N-acetylcysteine (NAC) is a mucolytic compound with antioxidant and anti-inflammatory effects. This study aimed to investigate the potential therapeutic effects of NAC against chronic noise-induced depression- and anxiety-like behaviors in mice. Methods: Fifty male BALB/c mice were randomly divided into 5 groups: control, noise90 dB, noise110 dB, noise 90+NAC, and noise 110+NAC groups. Animals in the noise groups were exposed to the 90 and 110 dB 2 h/day for 30 days. NAC groups received NAC (325 mg/kg P.O.) 20 min after being exposed to noise. To evaluate depressive- and anxiety-like behaviors, mice were subjected to open field test (OFT), sucrose preference test (SPT), tail suspension test (TST), and elevated plus maze (EPM) tasks. At the end of the behavioral tests, animals were sacrificed and levels of malondialdehyde (MDA), total antioxidant capacity (TAC), superoxide dismutase (SOD), and glutathione peroxidase (GPx) were determined in the hippocampus (HIP) and the prefrontal cortex (PFC). Results: The results showed that exposure to noise would induce anxiety- and depressive-like behaviors, being reversed by NAC administration. Moreover, chronic administration of NAC resulted in a significant increase in antioxidant enzyme activities and reduced lipid peroxidation (MDA levels) in the PFC and HIP of noise-exposed mice. Conclusion: Our findings revealed that the administration of NAC would reduce the adverse effects of noise on the brain and would exert anti-depressant and anxiolytic effects.

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Open field behavior and intra-nucleus accumbens dopamine release in vivo in virgin and lactating rats.

Cited by 9 publications

References 51 publications

Memory and exploratory behavior impairment in ovariectomized Wistar rats

Memory and exploratory behavior impairment in ovariectomized Wistar rats

Postpartum Lactation-Mediated Behavioral Outcomes and Drug Responses in a Spontaneous Mouse Model of Obsessive–Compulsive Disorder

Effects of N-acetylcysteine on Noise Exposure-induced Oxidative Stress and Depressive- and Anxiety-like Behaviors in Adult Male Mice

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