Effects of dietary nucleotide supplementation on growth performance and physiology of broiler chickens under pre- and post-inflammatory challenge

Kreuz, B; Rocha, Gabriel Cipriano; Campos, Paulo Henrique Reis Furtado; Silva, Fabyano F.; Hannas, Melissa Izabel; Albino, Luiz Fernando Teixeira; Borges, Samuel Oliveira; Calderano, Arele Arlindo

doi:10.37496/rbz4920200117

Cited by 5 publications

(4 citation statements)

References 33 publications

(40 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The greater availability of this genomic material could support enterocyte growth and mucosal development in the duodenum of early-weaned piglets. There was a consequent increase in villus height of early-weaned piglets, consistent with a previous report [31] that observed the effect of yeast-derived nucleotides on maintaining intestinal morphology. Furthermore, piglets fed an HY-supplemented diet have the ability to utilize nutrients and energy more efficiently for growth rather than enterocyte proliferation to repair the epithelial cell damage caused by pathogen infection or inflammatory response.…”

Section: Intestinal Morphologysupporting

confidence: 92%

“…Furthermore, piglets fed an HY-supplemented diet have the ability to utilize nutrients and energy more efficiently for growth rather than enterocyte proliferation to repair the epithelial cell damage caused by pathogen infection or inflammatory response. This was observed by the lower crypt depth values in the duodenum, which is consistent with previous findings [31]. However, Keimer et al [20] did not observe any changes in crypt depth in nursery pigs.…”

Section: Intestinal Morphologysupporting

confidence: 89%

See 1 more Smart Citation

Hydrolyzed Yeast Supplementation to Newly Weaned Piglets: Growth Performance, Gut Health, and Microbial Fermentation

Boontiam

Bunchasak

Cho

et al. 2022

Animals

View full text Add to dashboard Cite

Hydrolyzed yeast (HY)-derived protein from Saccharomyces cerevisiae has a high digestible protein content and nucleotides and is a sweetener immunostimulatory substance. This could be used in nursery diets to minimize diarrhea and improve the growth rate and gut health of early-weaned piglets. This research was conducted with the objective of examining the effect of the inclusion level of HY as a potential protein ingredient for early-weaned piglets. A total of 72 crossbred weaned piglets [(Landrace × Large White) × Duroc] were assigned to three dietary treatments in six replicates with four pigs per pen. Dietary treatments were: (i) control (CON), piglets weaned at 18 days; (ii) CON diet with 5% HY inclusion (HY5); and (iii) CON diet with 10% HY inclusion (HY10) in a corn–soybean meal-based basal diet. Increasing HY levels positively improved body weight, average daily gain, and average daily feed intake (linear effect, p < 0.05). Furthermore, there was a linear increase in N-retention, albumin, jejunal villus height, villus height-to-crypt depth ratio, immunoglobulin A, acetate and propionate production, and Lactobacillus spp. count proportional to the dose of the HY-supplemented diet (p < 0.05). It also observed a decrease in diarrheal rate, jejunal crypt depth, blood urea nitrogen, pro-inflammatory cytokines, branched amino acids, and E. coli corresponding to the HY-supplemented levels (p < 0.05). However, the changes in the apparent total tract digestibility (dry matter, crude ash, and crude fat), blood glucose, butyrate, and Salmonella spp. were unaffected by the dietary HY level. Therefore, the supplementation of HY in the diet for early-weaned pigs not only supported the growth rate and immune function but also activated the beneficial bacterial growth of the early-weaned piglets.

show abstract

Section: Intestinal Morphologysupporting

confidence: 92%

Section: Intestinal Morphologysupporting

confidence: 89%

Hydrolyzed Yeast Supplementation to Newly Weaned Piglets: Growth Performance, Gut Health, and Microbial Fermentation

Boontiam

Bunchasak

Cho

et al. 2022

Animals

View full text Add to dashboard Cite

show abstract

“…Dietary nucleotide supplementation improves the performance of broilers from seven to 20 days of age. However, from 21 to 35 days of age, supplementation of 0.3 g of purified nucleotide/kg of feed, independent of inflammatory challenge, does not contribute to improve performance of broilers (Kreuz et al, 2020). Diets supplemented with nucleotides did not influence broiler performance or carcass yield at 42 days of age, and were not different from the feeds not containing any additive or with AGP.…”

Section: Introductionmentioning

confidence: 85%

Blood Profile and Carcass Production of Broiler Chickens Given Nucleotides and Turmeric Extract in Feed

2022

View full text Add to dashboard Cite

Broiler chickens are birds that grow very fast, but have low body resistance and are easily stressed. This study aimed to examine the effect of nucleotide and turmeric extract (Curcuma longa Linn) on blood profile (erythrocytes, hemoglobin and leukocytes) and carcass production (weight of carcass, weight of breast, thighs and wings) in broiler chickens. Data was collected using a completely randomized design with 7 treatments consisting of Control: basal feed + antibiotic Bacitracin Zinc 0.1 g/day; N 0 : basal feed; N 1 : basal feed + turmeric extract 600 mg/kg feed; N 2 : basal feed + nucleotide 250 mg/kg feed; N 3 : basal feed + nucleotide 250 mg/kg feed + turmeric extract 600 mg/kg feed; N 4 : basal feed + nucleotide 500 mg/kg feed; N 5 : basal feed + nucleotide 500 mg/kg feed + turmeric extract 600 mg/kg feed. The results showed that nucleotide supplementation and turmeric extract had no significant effect on weight of carcass, weight of breast, thighs and wings, hemoglobin, erythrocytes and leukocytes of broiler. The use of nucleotide and turmeric extract could not improve the blood profile of broiler.

show abstract

“…The application of LPS is commonly used to stimulate the inflammatory response of broilers experimentally (Chen et al, 2020;Kreuz et al, 2020;Qiu et al, 2022). This was again confirmed by this study's results: worsening performance, lymphoid organ hypertrophy, and mRNA content of GSS.…”

Section: Controlmentioning

confidence: 99%

Digestible methionine + cysteine:digestible lysine ratio in diets for broilers submitted to inflammatory challenge

Borges

View full text Add to dashboard Cite

To estimate the ideal digestible (dig) Methionine (Met) + Cysteine (Cys):dig Lysine (Lys) ratio for broilers submitted or not to lipopolysaccharides (LPS) (E. coli) inflammatory challenge, 384 thirteen-day-old male chickens were distributed in a 4 x 2 (four ratios x with or without challenge) factorial completely randomized design, with eight replicates per treatment and six chickens per experimental unit (EU). The unchallenged birds received an application of saline solution (SS). The experimental diets were formulated to meet nutritional recommendations except for the dig Met + Cys levels, which varied according to the treatments. To obtain the experimental diets, a ration with a ratio of 0.69 dig Met + Cys:dig Lys was initially prepared, and later a diet with a ratio of 0.84. These rations were mixed in the appropriate proportions to obtain diets with ratios of 0.74 and 0.79. Parameters evaluated at 21 days of age included broilers’ performance, specifically weight gain (WG), feed intake (FI), and feed conversion ratio (FCR). Further parameters were jejunum mRNA content of nuclear factor kappa-B (NF-Κb), glutathione peroxidase (GPX), superoxide dismutase (SOD), glutathione synthetase (GSS), methionine adenosyltransferase (MAT2), cystathionine β-synthase (CBS), relative weights of liver and spleen, and dual-energy x-ray absorptiometry (DEXA) estimated fat mass (%) and lean mass (%). The differences were considered significant at an alpha level of 0.05. A linear regression model was used to evaluate the effects of the dig Met + Cys:dig Lys ratio on the evaluated parameters. There was no interaction (P > 0.05) between the inflammatory challenge and the increase of dig Met + Cys: dig Lys ratio for WG, FI, FCR, the relative weight of liver and spleen, and mRNA content of NF-Κb, GPX, SOD, GSS, MAT2, and CBS. The different ratios had no significant effect (P > 0.05) on the same data. However, there were significant differences (P < 0.05) between challenged and unchallenged animals. Chickens that received an intraperitoneal application of LPS all had lower performance parameters, and the liver and spleen had heavier and lower expression of GSS than those that received SS. No significant differences (P > 0.05) were observed concerning DEXA estimated fat and lean mass. Thus, the lowest dig Met + Cys:dig Lys ratio, that is 0.69 (1.193% dig Lys: 0.823% dig Met + Cys), was sufficient to maintain the parameters evaluated. Keywords: Sulfur amino acids. Poultry. LPS. E. coli.

show abstract

Effects of dietary nucleotide supplementation on growth performance and physiology of broiler chickens under pre- and post-inflammatory challenge

Cited by 5 publications

References 33 publications

Hydrolyzed Yeast Supplementation to Newly Weaned Piglets: Growth Performance, Gut Health, and Microbial Fermentation

Hydrolyzed Yeast Supplementation to Newly Weaned Piglets: Growth Performance, Gut Health, and Microbial Fermentation

Blood Profile and Carcass Production of Broiler Chickens Given Nucleotides and Turmeric Extract in Feed

Digestible methionine + cysteine:digestible lysine ratio in diets for broilers submitted to inflammatory challenge

Contact Info

Product

Resources

About