A Revista Brasileira de Oftalmologia e a indexação de periódicos bilíngues em Medicina

Damasceno, Eduardo de França; Rodrigues, Marcio Penha Mortera; Damasceno, Nadyr A; Neves, Ricardo de Almeida; Colombini, Giovanni Nicola Umberto Italiano; Damasceno, Daniel F

doi:10.37039/1982.8551.20230001

Cited by 2 publications

(9 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Overall, G3P [8] was the most prominent genotype (45.3%), followed by G1P [8] (32.1%), G9P [8] (6.8%), and G2P[4] (6.1%). The other unusual combinations, such as G1P [4], G1P [6], G2P [6], G3P [4], G3P [6], and G9P [6] were present in minor quantity.…”

Section: Distribution Of G and P Genotypesmentioning

confidence: 92%

“…G1P [4] G1P [6] G1P [8] G2P [4] G2P [8] G2P [6] G3P [4] G3P [6] G3P [8] G9P [4] G9P [8] F I G U R E 2 Fluctuation of major rotavirus A genotypes during 2017-2021, Dhaka, Bangladesh.…”

Section: Years Of Surveillancementioning

confidence: 99%

“…and P [8]. [4][5][6] Virus evolution results from the accumulation of point mutations and genome reassortment, which can occur when individual cells are dually infected by different strains of RVA. This process leads to the emergence of viral progeny carrying combinations of the parental genomes.…”

Section: Introductionmentioning

confidence: 99%

“…1 Globally, more than 90% of circulating RVA can typically be attributed to six combinations of G and P genotypes: G1P [8], G2P [4], G3P [8], G4P [8], G9P [8], and G12P [8]. 7,8 On a global scale, the most common genotypes identified, taking into account their prevalence, were G1P [8], G1P [6], and G3P [8]. The distribution of genotypes differed between countries that had implemented rotavirus vaccination and those that had not.…”

Section: Introductionmentioning

confidence: 99%

“…2 To date, 41G and 57P genotypes have been approved by the Rotavirus Classification Working Group (https:// rega.kuleuven.be/cev/viralmetagenomics/virus-classification/rcwg). 3 Worldwide, in human populations, the most prevalent G types are G1, G2, G3, G4, G9, and G12, while the predominant P types are P [4], P [6],…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Rotavirus trends and distribution of genotypes before and during COVID‐19 pandemic era: Bangladesh, 2017–2021

Haque,

Talha,

Rahman

et al. 2024

Journal of Medical Virology

View full text Add to dashboard Cite

Rotavirus gastroenteritis is accountable for an estimated 128 500 deaths among children younger than 5 years worldwide, and the majority occur in low‐income countries. Although the clinical trials of rotavirus vaccines in Bangladesh revealed a significant reduction of severe rotavirus disease by around 50%, the vaccines are not yet included in the routine immunization program. The present study was designed to provide data on rotavirus diarrhea with clinical profiles and genotypes before (2017–2019) and during the COVID‐19 pandemic period (2020–2021). Fecal samples were collected from 2% of the diarrheal patients at icddr,b Dhaka hospital of all ages between January 2017 and December 2021 and were tested for VP6 rotavirus antigen using ELISA. The clinical manifestations such as fever, duration of diarrhea and hospitalization, number of stools, and dehydration and so on were collected from the surveillance database (n = 3127). Of the positive samples, 10% were randomly selected for genotyping using Sanger sequencing method. A total of 12 705 fecal samples were screened for rotavirus A antigen by enzyme immunoassay. Overall, 3369 (27%) were rotavirus antigen‐positive, of whom children <2 years had the highest prevalence (88.6%). The risk of rotavirus A infection was 4.2 times higher in winter than in summer. Overall, G3P[8] was the most prominent genotype (45.3%), followed by G1P[8] (32.1%), G9P[8] (6.8%), and G2P[4] (6.1%). The other unusual combinations, such as G1P[4], G1P[6], G2P[6], G3P[4], G3P[6], and G9P[6], were also present. Genetic analysis on Bangladeshi strains revealed that the selection pressure (dN/dS) was estimated as <1. The number of hospital visits showed a 37% drop during the COVID‐19 pandemic relative to the years before the pandemic. Conversely, there was a notable increase in the rate of rotavirus positivity during the pandemic (34%, p < 0.00) compared to the period before COVID‐19 (23%). Among the various clinical symptoms, only the occurrence of watery stool significantly increased during the pandemic. The G2P[4] strain showed a sudden rise (19%) in 2020, which then declined in 2021. In the same year, G1P[8] was more prevalent than G3P[8] (40% vs. 38%, respectively). The remaining genotypes were negligible and did not exhibit much fluctuation. This study reveals that the rotavirus burden remained high during the COVID‐19 prepandemic and pandemic in Bangladesh. Considering the lack of antigenic variations between the circulating and vaccine‐targeted strains, integrating the vaccine into the national immunization program could reduce the prevalence of the disease, the number of hospitalizations, and the severity of cases.

show abstract

Section: Distribution Of G and P Genotypesmentioning

confidence: 92%

“…G1P [4] G1P [6] G1P [8] G2P [4] G2P [8] G2P [6] G3P [4] G3P [6] G3P [8] G9P [4] G9P [8] F I G U R E 2 Fluctuation of major rotavirus A genotypes during 2017-2021, Dhaka, Bangladesh.…”

Section: Years Of Surveillancementioning

confidence: 99%