Preliminary study of rabbits as an animal model of mammalian eye transplantation and literature review

Badaro, Emmerson; Cassini, Paula; Andrade, Gabriel Costa de; Rodrigues, Gustavo Büchele; Novais, Eduardo Amorim; Rodrigues, Eduardo Büchele

doi:10.37039/1982.8551.20220026

Cited by 2 publications

(4 citation statements)

References 13 publications

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“…Fourteen articles utilized mammalian and cadaveric models. 2,[11][12][13][14][15][16][17][18][19][20][21][22][23] The remaining 19 utilized cold-blooded species. [3][4][5][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39] After data extraction, a total of 1998 eyes were included, 1831 of which belonged to nonmammalian organisms and 167 to mammals, including 13 human cadavers and two living humans.…”

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…49,50 Beyond successful preservation of harvested allograft tissue, retinal function after WET with ON coaptation was demonstrated in 29 of 35 transplanted mammalian eyes with positive ERG results. 12,14,17,21 Bridging mammalian models to humans, Abbas et al utilized eyes of recently deceased individuals and concluded that hypoxia and acidification were the major factors impacting retinal viability. 48 The study found that the retina had the potential to remain viable for up to 20…”

Section: Ocular Functionality and The Nervous Systemmentioning

confidence: 99%

“…2,[11][12][13] After Sher et al performed the first vascular anastomosis within the context of ocular transplantation in mammals, 16 all future WET allografts remained viable in the immediate posttransplantation period. 15,17,21,22 Likewise, while initial instances of WET occurred in heterotopic sites, later transplantation of the eye to orthotopic sites resulted in success.…”

Section: Anatomic and Vascular Considerationsmentioning

confidence: 99%

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Technical Feasibility of Whole-eye Vascular Composite Allotransplantation: A Systematic Review

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et al. 2023

Plastic and Reconstructive Surgery - Global Open

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Background: There are over 43 million individuals in the world who are blind. As retinal ganglion cells are incapable of regeneration, treatment modalities for this condition are limited. Since first incepted in 1885, whole-eye transplantation (WET) has been proposed as the ultimate cure for blindness. As the field evolves, different aspects of the surgery have been individually explored, including allograft viability, retinal survival, and optic nerve regeneration. Due to the paucity in the WET literature, we aimed to systematically review proposed WET surgical techniques to assess surgical feasibility. Additionally, we hope to identify barriers to future clinical application and potential ethical concerns that could be raised with surgery. Methods: We conducted a systematic review of PubMed, Embase, Cochrane Library, and Scopus from inception to June 10, 2022, to identify articles pertaining to WET. Data collection included model organisms studied, surgical techniques utilized, and postoperative functional outcomes. Results: Our results yielded 33 articles, including 14 mammalian and 19 cold-blooded models. In studies performing microvascular anastomosis in mammals, 96% of allografts survived after surgery. With nervous coaptation, 82.9% of retinas had positive electroretinogram signals after surgery, indicating functional retinal cells after transplantation. Results on optic nerve function were inconclusive. Ocular-motor functionality was rarely addressed. Conclusions: Regarding allograft survival, WET appears feasible with no complications to the recipient recorded in previous literature. Functional restoration is potentially achievable with a demonstrated positive retinal survival in live models. Nevertheless, the potential of optic nerve regeneration remains undetermined.

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