Heart Transplantation for Chagas Cardiomyopathy

Moreira, Maria da Consolação Vieira; Castilho, Fábio Morato de; Braulio, Renato; Andrade, Guilherme Ferraz Messina de Pádua; Melo, José Renan da Cunha

doi:10.36660/ijcs.20200248

Cited by 2 publications

(4 citation statements)

References 35 publications

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“… 644 O diagnóstico diferencial entre a miocardite da rejeição e da reativação ainda constitui um grande desafio. 390 , 644 , 654 Na presença de infiltrado inflamatório, ninhos de amastigotas e/ou PCR positiva para T. cruzi no miocárdio, podemos afirmar que existe reativação, mas não é possível excluir, com segurança, rejeição do enxerto associada. Apesar dessa complexidade, a taxa de sobrevida de receptores com CCDC submetidos ao TC não difere das de outras etiologias.…”

Section: 2 Recursos Não Farmacológicosunclassified

“… 644 The differential diagnosis between myocarditis of rejection and of reactivation is still a great challenge. 390 , 644 , 654 In the presence of inflammatory infiltrate, nests of amastigotes and/or positive PCR for T. cruzi in the myocardium, we can claim that reactivation is present, but associated graft rejection cannot be safely excluded. Despite this complexity, the survival rate of recipients with CCCD undergoing CTX does not differ from those of cardiomyopathies of other etiologies.…”

Section: 2 Non-pharmacological Resourcesmentioning

confidence: 99%

“…26 Nesse sentido e quando se revisitam e elaboram diretrizes, torna-se plenamente justificável reconhecer a excepcional contribuição dos médicos e cientistas eméritos que nos deixaram justo quando se publicava a de 2011, e agora, quando finalizamos a de 2022. Entre tantos outros, cujos nomes aqui omitimos por razão de espaço, queremos reverenciar a memória ilustre dos Professores Joaquim Romeu Cançado 1913-2011 (Belo Horizonte), Aluízio Rosa Prata 1920-2011 (Uberaba), desaparecidos há já uma década, e de Zilton Araújo Andrade 1924Andrade -2020 (Salvador), José Rodrigues Coura 1927-2021 (Rio de Janeiro) e Anis Rassi 1929-2021 (Goiânia), que mais recentemente nos legaram a continuidade de seus trabalhos com a DC. A esses luminares devotamos, por ocasião e lembrança de seu passamento, nossa gratidão e o reconhecimento por permitirem, com sua influência nesta diretriz, nos mantermos na senda luminosamente científica traçada por Carlos Chagas.…”

Section: Considerações Iniciaisunclassified

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Diretriz da SBC sobre Diagnóstico e Tratamento de Pacientes com Cardiomiopatia da Doença de Chagas – 2023

Marin-Neto¹,

Rassi²,

Oliveira³

et al. 2023

Arquivos Brasileiros De Cardiologia

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Section: 2 Recursos Não Farmacológicosunclassified

Section: 2 Non-pharmacological Resourcesmentioning

confidence: 99%

Section: Considerações Iniciaisunclassified

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Diretriz da SBC sobre Diagnóstico e Tratamento de Pacientes com Cardiomiopatia da Doença de Chagas – 2023

Marin-Neto¹,

Rassi²,

Oliveira³

et al. 2023

Arquivos Brasileiros De Cardiologia

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“…*Correspondence: lis.antonelli@fiocruz.br progression is highly variable, and individuals may stay in an indeterminate clinical form for decades until the first clinical symptoms emerge. Chronic inflammation results in a tissue remodeling that leads to loss of function, and in several cases to the need for heart transplantation [7].…”

Section: Journal Of Translational Medicinementioning

confidence: 99%

Chagasic cardiomyopathy is marked by a unique signature of activated CD4+ T cells

et al. 2022

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Chagas disease is a neglected tropical disease in Latin America and an imported emerging disease worldwide. Chronic Chagas disease cardiomyopathy (CCC) is the most prominent clinical form and can lead to heart failure, thromboembolism, and sudden death. While previous reports have supported a role for CD4+ T lymphocytes in the pathogenesis of CCC a comprehensive analysis of these cells during different clinical forms is lacking. Here, we used high-dimensional flow cytometry to assess the diversity of circulating CD4+ T cells in patients with distinct clinical forms. We found increased frequencies of CD4+CD69+ T cells in patients compared to controls. CD39+ regulatory T cells, represented by mesocluster 6 were reduced in mild CCC patients compared to controls. Cytotoxic CD4+ T cells co-expressing granzyme B and perforin were expanded in patients with Chagas disease and were higher in patients with mild CCC compared to controls. Furthermore, patients with mild CCC displayed higher frequencies of multifunctional effector memory CD4+ T cells. Our results demonstrate an expansion in activated CD4+ T cells and a decrease in a functional subset of regulatory T cells associated with the onset of Chagas cardiomyopathy, suggesting their role in the establishment of cardiac lesions and as potential biomarkers for disease aggravation.

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Heart Transplantation for Chagas Cardiomyopathy

Cited by 2 publications

References 35 publications

Diretriz da SBC sobre Diagnóstico e Tratamento de Pacientes com Cardiomiopatia da Doença de Chagas – 2023

Diretriz da SBC sobre Diagnóstico e Tratamento de Pacientes com Cardiomiopatia da Doença de Chagas – 2023

Chagasic cardiomyopathy is marked by a unique signature of activated CD4+ T cells

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