Particularidades dos Pacientes com Arterite de Takayasu em Idade Mais Avançada: Estudo Coorte, Retrospectivo e Transversal

Oliveira, João Calvino Soares de; Santos, Alexandre Moura dos; Aguiar, Mariana Freitas de; Gonçalves, Jucier; Souza, Alexandre Wagner Silva de; Pereira, Rosa Maria Rodrigues; Shinjo, Samuel Katsuyuki

doi:10.36660/abc.20220463

Cited by 4 publications

References 28 publications

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Structural network topology correlates with cognitive impairment in Parkinson’s disease

Chen,

Li,

Zhou

et al. 2023

Preprint

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In patients with Parkinson's disease (PD), cognitive impairment is common and substantially exacerbates disease severity. The objective of this study is to investigate whether cognitive decline affects disease severity and whether structural network disruption contributes to cognitive impairment in PD patients. PD patients (n = 146) receiving structural and functional magnetic resonance imaging from Parkinson's Progression Markers Initiative (PPMI) database were included. Based on the scores of Symbol Digit Modalities Test (SDMT), patients were classified into lower quartile group (SDMT score rank: 0%~25%), interquartile group (SDMT score rank: 26%~75%), and upper quartile group (SDMT score rank: 76%~100%) according to their SDMT score quartiles to assess how cognitive function shapes disease manifestations and brain network topology. Patients in the lower quartile group exhibited more severe motor symptoms, non-motor symptoms, and striatal dopamine depletion compared to interquartile group and upper quartile group. In addition, they also showed impaired structural network topology both at global and local levels compared to interquartile group and upper quartile group. Furthermore, different nodal network metrics in structural network contributed to cognitive and motor impairment of PD patients. Taken together, PD patients with worse cognitive function exhibited more severe motor and non-motor symptoms and aberrant structural network metrics were associated with both cognitive and motor decline of PD patients.

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Structural network topology correlates with cognitive impairment in Parkinson’s disease

Chen,

Li,

Zhou

et al. 2023

Preprint

View full text Add to dashboard Cite

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Striatal dopamine depletion drives disease progression and network topology aberrations specifically by impairing left M1 network

Chen,

Li,

Zhou

et al. 2023

Preprint

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Background Stratal dopamine depletion contributes to both motor and non-motor symptoms of patients with Parkinson's disease (PD). The objective of current study is to explore whether stratal dopamine depletion shapes clinical heterogeneity by impairing brain networks of PD patients. Methods In this cross-sectional study, PD participants undergoing functional magnetic resonance imaging from Parkinson's Progression Markers Initiative (PPMI) database were investigated. According to the levels of striatal binding ratio (SBR) in bilateral striatum, PD patients were classified into lower quartile group (SBR level rank: 0%~25%), interquartile group (SBR level rank: 26%~75%), and upper quartile group (SBR level rank: 76%~100%) based on their SBR level quartiles to examine how stratal dopamine depletion affects clinical manifestations and brain networks. Findings PD patients in the lower quartile group showed more severe motor and non-motor symptoms compared to upper quartile group. Additionally, topological metrics in both structural and functional network were significantly different between upper quartile group and lower quartile group. Furthermore, the functional network of left primary motor cortex (M1) was specifically impaired in lower quartile group, which resulted in topological disruptions in functional network. Importantly, impaired left M1 network in PD patients mediated the effects of striatal dopamine depletion on both motor and non-motor symptoms. Interpretation Striatal dopamine depletion specifically impaired left M1 network, which contributed to aberrant functional network topology and dopamine-dependent motor and non-motor symptoms. Funding National Natural Science Foundation of China (Grant No. 81873778, 82071415) and National Research Center for Translational Medicine at Shanghai (Grant No. NRCTM(SH)-2021-03).

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Both brain network topology and striatal dopamine depletion mediate the effects of autonomic dysfunction on disease burden of Parkinson’s disease

Chen,

Li,

Zhou

et al. 2023

Preprint

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Background: Autonomic dysfunction is one of the most common non-motor symptoms in Parkinson's disease (PD). Whether autonomic dysfunction contributes to disease progression and brain network abnormalities in PD remain largely unknown. The objective of this study is to evaluate how autonomic dysfunction affects clinical features and brain networks of PD patients. Methods: PD patients from Parkinson's Progression Markers Initiative (PPMI) database were included if they received magnetic resonance imaging. According to the scores of Scale for Outcomes in Parkinson's Disease-Autonomic (SCOPA-AUT), PD patients were classified into lower quartile group (SCOPA-AUT score rank: 0%~25%), interquartile group (SCOPA-AUT score rank: 26%~75%), and upper quartile group (SCOPA-AUT score rank: 76%~100%) based on their SCOPA-AUT score quartiles to examine how autonomic dysfunction shapes clinical manifestations and brain networks. Results: PD patients in the upper quartile group showed more severe motor and non-motor symptoms, as well as more deficits in dopamine transporter binding compared to lower quartile group. Additionally, they also showed statistically different topological properties in structural and functional network compared to lower quartile group. Both structural and functional network metrics mediated the effects of autonomic dysfunction on clinical symptoms of PD patients. Reduced dopamine transporter binding also contributed to the effects of autonomic dysfunction on disease burden of PD patients. Conclusions: PD patients with more severe autonomic dysfunction exhibit worse disease and impairment of brain network topology. Both network topology and striatal dopamine depletion mediate the effects of autonomic dysfunction on clinical symptoms of PD patients.

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Particularidades dos Pacientes com Arterite de Takayasu em Idade Mais Avançada: Estudo Coorte, Retrospectivo e Transversal

Cited by 4 publications

References 28 publications

Structural network topology correlates with cognitive impairment in Parkinson’s disease

Structural network topology correlates with cognitive impairment in Parkinson’s disease

Striatal dopamine depletion drives disease progression and network topology aberrations specifically by impairing left M1 network

Both brain network topology and striatal dopamine depletion mediate the effects of autonomic dysfunction on disease burden of Parkinson’s disease

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