Pesquisando Compostos de Ocorrência Natural para Tratar Hipertensão

Abstract

Cardiovascular diseases (CDs) are the major cause of death worldwide. Impressively, approximately 17.9 million people died from CDs in 2019, representing almost 32% of global deaths. Also, nearly three-quarters of deaths due to CDs occur in low-and middle-income countries, which is a risk factor for Brazilians. 1 There are several underlying mechanisms involved in CDs, and hypertension is a significant contributor. Today, it is thought that about 1.28 billion adults aged 30-79 years have hypertension in the world. Furthermore, it has been estimated that 60-70% of hypertension in adults is attributable to obesity, associated with insulin resistance, dyslipidemia and metabolic syndrome. 2 Also, almost 50% of adults with hypertension are unaware of its condition, and only 20% have hypertension under control. 3

Sakuranetin as a Potential Regulator of Blood Pressure in Spontaneously Hypertensive Rats by Promoting Vasorelaxation through Calcium Channel Blockade

“…Natural compounds derived from medicinal plants have emerged as promising candidates for CVD treatment owing to their diverse pharmacological properties, which include antioxidant, anti-inflammatory, lipid-lowering, antithrombotic, and immunomodulatory effects [8,9]. Notably, natural compounds have demonstrated significant BP-lowering effects, with 82 natural compounds approved as antihypertensive agents by the Food and Drug Administration from 1981 to 2019 [10,11]. Moreover, these compounds exhibit relaxing effects, primarily through nitric oxide (NO)/cGMP (cyclic 3 ′ ,5 ′ -guanosine monophosphate) pathways or by blocking the Ca 2+ channels in the vascular smooth muscle cells (VSMCs), showcasing the therapeutic potential for hypertension [12,13].…”

“…Moreover, these compounds exhibit relaxing effects, primarily through nitric oxide (NO)/cGMP (cyclic 3 ′ ,5 ′ -guanosine monophosphate) pathways or by blocking the Ca 2+ channels in the vascular smooth muscle cells (VSMCs), showcasing the therapeutic potential for hypertension [12,13]. Given that some patients with high BP may not respond to or comply with conventional treatment medications, discovering new compounds for hypertension management is crucial [10].…”