Envelhecimento Vascular e Rigidez Arterial

The Effect of Age, Hypertension, and Overweight on Arterial Stiffness Assessed Using Carotid Wall Echo-Tracking in Childhood and Adolescence

“…The evaluation of the mechanical properties of CCA using the high-resolution echo-tracking method represents a highly accurate tool for evaluating changes in arterial diameter during the cardiac cycle and consequently calculating indices of stiffness and compliance of the arterial wall. With aging, the arteries undergo complex changes in their structure and function resulting from altered cellular mitotic rate and cytokine production, degradation of the extracellular matrix, and the deposition of less elastic structural components [ 20 ]. These changes are more evident in the tunica media of the proximal elastic segments and result in a progressive increase in arterial stiffness, which can be accelerated by various cardiovascular risk factors [ 20 , 21 ].…”

“…With aging, the arteries undergo complex changes in their structure and function resulting from altered cellular mitotic rate and cytokine production, degradation of the extracellular matrix, and the deposition of less elastic structural components [ 20 ]. These changes are more evident in the tunica media of the proximal elastic segments and result in a progressive increase in arterial stiffness, which can be accelerated by various cardiovascular risk factors [ 20 , 21 ]. Among these, elevated BP plays a pivotal role in the mechanisms that contribute to early vascular aging [ 7 , 22 ].…”

Aortic Stiffness Is Independently Associated with Intracranial Carotid Artery Calcification in Patients with Ischemic Stroke

“…It is also an independent predictor for diabetes, dementia, retinal and kidney disorders [19][20][21]. Arterial stiffness reflects long-term cumulative effects on the vascular tree, along with the effects of age and genetic predisposition, and if increased, increases vascular age and the cumulative risk of stroke, independently of traditional CVRFs [22]. Although traditional CVRFs for ICAC have already been investigated [12,23], their association with arterial stiffness, especially with the two distinct subtypes of ICAC, is unknown.…”

Rigidez Arterial e Previsão de Doença Renal Crônica

“…O aumento da VOP e da pressão arterial sistólica central têm sido identificados como preditores independentes de futuros eventos cardiovasculares e lesões de órgãos-alvo, como hipertrofia ventricular esquerda e aumento da microalbuminúria, e representam os limites entre fatores de risco cardiovascular e eventos cardiovasculares. 4 O Systolic Blood Pressure Intervention Trial (SPRINT) concluiu que a pressão arterial sistólica < 120mmHg não foi capaz de reduzir a progressão da DRC, mas reduziu o risco cardiovascular e a mortalidade em adultos sem diabetes, 5 mostrando a natureza multifatorial da progressão da DRC. O estudo CRIC mostrou que a VOP estava altamente associada à doença cardiovascular prevalente e essa associação era independente da pressão arterial sistólica.…”

“…Increased PWV and central systolic blood pressure have been identified as independent predictors of future cardiovascular events and target organ lesions, such as left ventricular hypertrophy and increased microalbuminuria, and they represent the limits between cardiovascular risk factors and cardiovascular events. 4 The Systolic Blood Pressure Intervention Trial (SPRINT) concluded that systolic blood pressure < 120mmHg was not able to reduce CKD progression, but it reduced cardiovascular risk and mortality in adults without diabetes, 5 showing the multifactorial nature of CKD progression. The CRIC study showed that PWV was highly associated with prevalent cardiovascular disease and this association was independent of systolic blood pressure.…”