Avaliação da Relação entre Níveis de Adropina e Circulação Colateral Coronária em Pacientes com Síndrome Coronariana Crônica

Akkaya, Hasan; Güntürk, Ertuğrul Emre; Akkaya, Fulya; Karabıyık, Uğur; Güntürk, İnayet; Yılmaz, Samet

doi:10.36660/abc.20210573

Cited by 4 publications

(1 citation statement)

References 32 publications

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“…There are many studies showing the protective role of adropin on endothelial structure and function. In a recent study, the relationship between adropin level and the development of CCC was shown in patients with chronic coronary syndrome [ 6 ]. In this study, we planned to examine the relationship between coronary collateral circulation, which is thought to develop rapidly in patients with acute myocardial infarction, and adropin levels.…”

Section: Introductionmentioning

confidence: 99%

The Relationship Between Coronary Collateral Circulation and Serum Adropin Levels

Vural¹,

Kurt²,

Karagöz³

et al. 2023

Cureus

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ObjectiveCoronary collateral circulation (CCC) are vascular structures that limit the infarct area, protect left ventricular function, and reduce the frequency of arrhythmia and mortality during myocardial ischemia and infarction. In this study, we examined the relationship between the development of CCC and serum adropin levels, which has been shown in previous studies to regulate endothelial functions and increase endothelial nitric oxide synthesis, in patients with acute myocardial infarction. MethodsThis study included 41 patients with insufficient CCC and 43 patients with well-developed CCC who were hospitalized for acute myocardial infarction and underwent coronary angiography. The Cohen-Rentrop classification was used to grade the CCC. The patients were divided into two groups according to Rentrop grades: those with a 0-1 stage were considered as insufficient and those with grades of 2-3 were considered as well-developed CCC. We took blood samples to measure the adropin levels within the first 24 hours of hospitalization. ResultsThe mean age was 59.1±11.9 years and 62 (73.8%) were male. The right coronary artery was the most frequently target vessel (n: 51, 60.7%), and the majority of the patients presented with ST-segment elevation myocardial infarction (STEMI) (n:58, 69%). The median interval between the severe chest pain and the intervention was significantly higher in patients with well-developed CCC (p=0.042). The serum adropin levels in patients with insufficient CCC were significantly lower than in those with well-developed CCC (196.3 [131.5 -837.0] pg/mL vs. 235.5 [171.9 -1124.2] pg/mL, p<0.001). Logistic regression analysis revealed that the circumflex artery as the target vessel, NSTEMI (non-STEMI) as the type of myocardial infarction, and serum adropin level were the independent risk factors for the prediction of poor coronary collateral vessel formation (p<0.05). ConclusionsIn this study, we found that in patients with acute myocardial infarction, those with well-developed CCC had higher adropin levels.

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Section: Introductionmentioning

confidence: 99%

The Relationship Between Coronary Collateral Circulation and Serum Adropin Levels

Vural¹,

Kurt²,

Karagöz³

et al. 2023

Cureus

View full text Add to dashboard Cite

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Emerging Evidence Linking the Liver to the Cardiovascular System: Liver-derived Secretory Factors

Liu¹,

Shao²,

Han³

et al. 2023

J Clin Transl Hepatol

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Adropin’s Role in Energy Homeostasis and Metabolic Disorders

Ali

D’Souza

Singh

et al. 2022

IJMS

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Adropin is a novel 76-amino acid-peptide that is expressed in different tissues and cells including the liver, pancreas, heart and vascular tissues, kidney, milk, serum, plasma and many parts of the brain. Adropin, encoded by the Enho gene, plays a crucial role in energy homeostasis. The literature review indicates that adropin alleviates the degree of insulin resistance by reducing endogenous hepatic glucose production. Adropin improves glucose metabolism by enhancing glucose utilization in mice, including the sensitization of insulin signaling pathways such as Akt phosphorylation and the activation of the glucose transporter 4 receptor. Several studies have also demonstrated that adropin improves cardiac function, cardiac efficiency and coronary blood flow in mice. Adropin can also reduce the levels of serum triglycerides, total cholesterol and low-density lipoprotein cholesterol. In contrast, it increases the level of high-density lipoprotein cholesterol, often referred to as the beneficial cholesterol. Adropin inhibits inflammation by reducing the tissue level of pro-inflammatory cytokines such as tumor necrosis factor alpha and interleukin-6. The protective effect of adropin on the vascular endothelium is through an increase in the expression of endothelial nitric oxide synthase. This article provides an overview of the existing literature about the role of adropin in different pathological conditions.

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Avaliação da Relação entre Níveis de Adropina e Circulação Colateral Coronária em Pacientes com Síndrome Coronariana Crônica

Cited by 4 publications

References 32 publications

The Relationship Between Coronary Collateral Circulation and Serum Adropin Levels

The Relationship Between Coronary Collateral Circulation and Serum Adropin Levels

Emerging Evidence Linking the Liver to the Cardiovascular System: Liver-derived Secretory Factors

Adropin’s Role in Energy Homeostasis and Metabolic Disorders

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