Índice de Inflamação Imune Sistêmica é Preditor de Eventos Cardiovasculares Adversos Maiores em Pacientes com Infarto Agudo do Miocárdio com Supradesnivelamento do Segmento ST

Şaylık, Faysal; Akbulut, Tayyar

doi:10.36660/abc.20210412

Arquivos Brasileiros De Cardiologia

2022

DOI: 10.36660/abc.20210412

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Índice de Inflamação Imune Sistêmica é Preditor de Eventos Cardiovasculares Adversos Maiores em Pacientes com Infarto Agudo do Miocárdio com Supradesnivelamento do Segmento ST

Faysal Şaylık¹,

Tayyar Akbulut²

Abstract: Resumo Fundamento O índice de inflamação imune sistêmica (SII, systemic immune-inflammation index) tem sido descrito como um novo marcador prognóstico em tumores e doenças cardiovasculares. Objetivos Investigar a associação entre eventos cardiovasculares adversos em pacientes com infarto agudo do miocárdio com supradesnivelamento do segmento ST (IAMCSST). Métodos Foi realizado um estudo observacional retrospectivo em 843 paciente… Show more

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Cited by 7 publications

References 39 publications

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Prognostic value of Geriatric Nutritional Risk Index and systemic immune-inflammatory index in elderly patients with acute coronary syndromes

Zhu,

Zhang,

et al. 2024

Sci Rep

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The objective of this study was to evaluate the predictive value of the Geriatric Nutritional Risk Index (GNRI) combined with the Systemic Immunoinflammatory Index (SII) for the risk of major adverse cardiovascular events (MACE) following percutaneous coronary intervention in elderly patients with acute coronary syndrome (ACS). We retrospectively reviewed the medical records of 1202 elderly patients with acute coronary syndromes divided into MACE and non-MACE groups according to whether they had a MACE. The sensitivity analysis utilized advanced machine learning algorithms to preliminarily identify the critical role of GNRI versus SII in predicting MACE risk. We conducted a detailed analysis using a restricted cubic spline approach to investigate the nonlinear relationship between GNRI, SII, and MACE risk further. We constructed a clinical prediction model based on three key factors: GNRI, SII, and Age. To validate the accuracy and usefulness of this model, we compared it to the widely used GRACE score using subject work and recall curves. Additionally, we compared the predictive value of models and GRACE scores in assessing the risk of MACE using the Integrated Discriminant Improvement Index (IDI) and the Net Reclassification Index (NRI). This study included 827 patients. The GNRI scores were lower in the MACE group than in the non-MACE group, while the SII scores were higher in the MACE group (P < 0.001). The multifactorial analysis revealed a low GNRI (OR = 2.863, 95% CI: 2.026–4.047, P = 0.001), High SII (OR = 3.102, 95% CI: 2.213–4.348, P = 0.001). The area under the curve (AUC) for the predictive model was 0.778 (95% CI: 0.744–0.813, P = 0.001), while the AUC for the GRACE score was 0.744 (95% CI: 0.708–0.779, P = 0.001). NRI was calculated to be 0.5569, with NRI + at 0.1860 and NRI- at 0.3708. The IDI was found to be 0.0571, with a P-value of less than 0.001. These results suggest that the newly developed prediction model is more suitable for use with the population in this study than the GRACE score. The model constructed using GNRI and SII demonstrated good standardization and clinical impact, as evidenced by the standard, DCA, and clinical impact curves. The study shows that combining GNRI and SII can be a simple, cost-effective, and valuable way to predict the risk of MACE within one year in elderly acute coronary syndromes.

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Prognostic value of Geriatric Nutritional Risk Index and systemic immune-inflammatory index in elderly patients with acute coronary syndromes

Zhu,

Zhang,

et al. 2024

Sci Rep

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Prognostic value of systemic immune‐inflammation index in CAD patients: Systematic review and meta‐analyses

Zhao,

Zhang,

Sun

et al. 2023

Eur J Clin Investigation

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BackgroundSystemic immune‐inflammation index (SII) is a novel inflammatory marker based on neutrophils, platelets and lymphocytes counts, which has potential prognostic value among coronary artery disease (CAD) patients as described by some observational studies. We aimed to provide higher‐certainty evidence to verify the association of SII with poor outcomes of CAD patients.MethodsPubMed, Web of Science, Embase, Ovid and Scopus were searched to find relevant literature exploring the prognostic value of SII among CAD patients. Hazard ratios (HRs) with 95% confidence intervals (CIs) extracted from the literature included were pooled with the fixed‐effect or random‐effect model. Sensitivity analyses and subgroup analyses were conducted to detect the source of heterogeneity and evaluate the stability of results.ResultsA total of nine studies with 15,832 participants were included. The quantitative synthesis including eight studies with 15,657 participants showed that the high SII was related to the major adverse cardiovascular event in CAD patients (HR with 95% CI: 2.36 [1.67, 3.33]). After eliminating heterogeneity and adjusting for publication bias, the above result was still robust (HR with 95% CI: 1.67 [1.32, 2.12]). Additionally, we also demonstrated the prognostic values of SII for all‐cause death, cardiovascular death, myocardial infarction and stroke.ConclusionHigher SII has prognostic values for adverse outcomes in CAD patients.

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Association Between Systemic Immune Inflammation Level and Poor Prognosis Across Different Glucose Metabolism Status in Coronary Artery Disease Patients

Xu,

Xie,

et al. 2023

JIR

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Índice de Inflamação Imune Sistêmica é Preditor de Eventos Cardiovasculares Adversos Maiores em Pacientes com Infarto Agudo do Miocárdio com Supradesnivelamento do Segmento ST

Cited by 7 publications

References 39 publications

Prognostic value of Geriatric Nutritional Risk Index and systemic immune-inflammatory index in elderly patients with acute coronary syndromes

Prognostic value of Geriatric Nutritional Risk Index and systemic immune-inflammatory index in elderly patients with acute coronary syndromes

Prognostic value of systemic immune‐inflammation index in CAD patients: Systematic review and meta‐analyses

Association Between Systemic Immune Inflammation Level and Poor Prognosis Across Different Glucose Metabolism Status in Coronary Artery Disease Patients

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