Aterosclerose e Inflamação: Ainda Muito Caminho a Percorrer

Wang, Ricardo; Nascimento, Bruno Ramos; Neuenschwander, Fernando Carvalho

doi:10.36660/abc.20200219

Cited by 2 publications

(2 citation statements)

References 15 publications

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“…It has been known that activation of immune cells and inflammatory cytokines has a key role in the process, particularly T cell-mediated pathogenic immune responses, such as CD4 + T lymphocytes. 19 The CD4 + T lymphocytes in the atherosclerosis lesion are major consisted of Th1 and Th17 cells. 20 Natural Tregs, as an important subset of T lymphocytes, could regulate peripheral immune homeostasis by balancing the Th1, Th2 and Th17.…”

Section: Discussionmentioning

confidence: 99%

GARP and GARP-Treated tDC Prevented the Formation of Atherosclerotic Plaques in ApoE−/- Mice

Cai

Zeng

Liu³

et al. 2021

JIR

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Purpose This study aims to clarify the specific mechanism by which GARP affects the atherosclerotic plaques in ApoE −/- mice and the effect of GARP-tDC on atherosclerosis. Methods The mice were randomly divided into three groups: the control group, the GARP-overexpressed group and the GARP-inhibited group. After 12 weeks, all the mice were euthanized, and the specimens were collected. In vitro, experiments were conducted to observe the effect of GARP on DC phenotype and the changes of the proportion of CD4 + CD25 + Foxp3 + Treg cells when GARP-tDCs were co-cultured with CD4 + T cells. Furthermore, adoptive transmission of GARP-tDCs was used to observe the effect on atherosclerotic plaque in mice. Results The GARP-overexpressed group enhanced the biological activity of Foxp3 + CD4 + CD25 + Tregs and resulted in increased expression of LAP in T cells. In addition, the GARP-overexpressed group significantly suppressed the function of Th1 and Th17, and decreased the secretion of INF-γ and IL-17A. Thus, GARP had a protective effect on atherosclerosis. In vitro, we found that GARP-tDC had a tolerance-inducing phenotype, and GARP-tDC also had the ability to induce tolerance when co-cultured with CD4 + T cells. More importantly, adoptive transmission of GARP-tDCs reduced the size of atherosclerotic plaques. Conclusion GARP and the GARP-tDC play protective roles in atherosclerosis. The protective effect of GARP on atherosclerosis is achieved by increasing CD4 + CD25 + Foxp3 + Treg cells and inhibiting the production of IFN-γ and IL-17A.

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Section: Discussionmentioning

confidence: 99%

GARP and GARP-Treated tDC Prevented the Formation of Atherosclerotic Plaques in ApoE−/- Mice

Cai

Zeng

Liu³

et al. 2021

JIR

View full text Add to dashboard Cite

show abstract

“…7 21 st -century medicine offers a great armamentarium of molecular diagnoses for several diseases, but CAD is somewhat lacking behind. 8 It is widely known that inflammation plays a major role in atherogenesis; 9 thus, several biomarkers have been studied in this context, such as C-reactive Protein, Interleukin (IL)6, Tumor Necrosis Factor (TNF) alfa, among others. [10][11][12] One of these tools' mean issues is the lack of specificity or its right association with net mortality.…”

mentioning

confidence: 99%

Devemos “Ajustar” Nossa Abordagem à Doença Arterial Coronariana?

Rendon¹

2022

Arquivos Brasileiros De Cardiologia

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Aterosclerose e Inflamação: Ainda Muito Caminho a Percorrer

Cited by 2 publications

References 15 publications

GARP and GARP-Treated tDC Prevented the Formation of Atherosclerotic Plaques in ApoE−/- Mice

GARP and GARP-Treated tDC Prevented the Formation of Atherosclerotic Plaques in ApoE−/- Mice

Devemos “Ajustar” Nossa Abordagem à Doença Arterial Coronariana?

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