Obesidade Visceral e Hipertensão Sistólica como Substratos da Disfunção Endotelial em Adolescentes Obesos

Hussid, Maria Fernanda; Cepeda, Felipe X.; Jordão, Camila Paixão; Lopes-Vicente, Rafaela R. P.; Virmondes, Leslie; Katayama, Keyla Yukari; Oliveira, Ezequiel Fernandes; Oliveira, Luís Vicente Franco de; Consolim‐Colombo, Fernanda Marciano; Trombetta, Ivani C.

doi:10.36660/abc.20190541

Cited by 5 publications

(2 citation statements)

References 25 publications

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“…Finally, the following 103 articles were selected: [ 24 – 34 , 44 – 135 ] after the evaluation of the full texts, 78 were excluded for the following reasons: (1) the design of the studies did not meet the inclusion criteria defined for this review [ 44 – 46 , 48 – 53 , 55 – 57 , 59 – 61 , 65 , 66 , 68 – 73 , 79 , 81 , 84 , 86 , 88 – 91 , 97 , 100 – 104 , 106 , 108 , 110 , 112 – 117 , 119 – 122 , 124 – 132 , 134 , 135 ] (2) the studies did not present an evaluation of whole body FFM/LBM, these were [ 47 , 54 , 58 , 62 – 64 , 67 , 74 – 78 , 80 , 82 , 83 , 85 , 92 – 96 , 105 , 107 , 109 , 111 , 123 ] and (3) another language [ 87 ] (Fig. 1 ).…”

Section: Resultsmentioning

confidence: 99%

Fat-free/lean body mass in children with insulin resistance or metabolic syndrome: a systematic review and meta-analysis

et al. 2022

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Background Lean / Fat Free Body Mass (LBM) is metabolically involved in active processes such as resting energy expenditure, glucose uptake, and myokine secretion. Nonetheless, its association with insulin sensitivity / resistance / glucose tolerance and metabolic syndrome remains unclear in childhood. Methods The current investigation aimed to examine the differences in fat-free mass /lean body mass according to the presence of insulin sensitivity/insulin resistance/glucose tolerance/metabolic syndrome in children. A systematic search was carried out in Medline/PubMed, Embase, Scopus, Web of Science, and SciELO, covering the period from each database’s respective start to 21 June 2021. Two researchers evaluated 7111 studies according to the inclusion criteria: original human studies, written in English or Spanish, evaluating fat-free mass/lean body mass in children and adolescents including both with and without insulin sensitivity/insulin resistance /glucose tolerance and metabolic syndrome and reported the differences between them in terms of fat free mass/lean body mass. The results of the studies were combined with insulin sensitivity, insulin, resistance, glucose tolerance and metabolic syndrome. The standardized mean difference (SMD) in each study was calculated and combined using the random-effects model. Heterogeneity between studies was tested using the index of heterogeneity (I2), leave-one-out sensitivity analyses were performed, and publication bias was assessed using the Egger and Begg tests. Results Finally, 15 studies which compared groups defined according to different glucose homeostasis criteria or metabolic syndrome out of 103 eligible studies were included in this systematic review and 12 studies in the meta-analysis. Meta-analysis showed lower fat-free mass/lean body mass percentage in participants with insulin resistance/glucose tolerance/metabolic syndrome (SMD -0.47; 95% CI, − 0.62 to − 0.32) while in mass units (kg), higher values were found in the same group (SMD, 1.01; 95% CI, 0.43 to 1.60). Conclusions Our results identified lower values of fat-free mass/lean body mass (%) in children and adolescents with insulin resistance/glucose tolerance/metabolic syndrome and higher values of fat-free mass/lean body mass when these are expressed in kg. The evidence of the impact of lean mass on children’s glucose homeostasis or metabolic syndrome is limited, so future studies research should focus on explaining the effect of fat-free mass/lean body mass on different metabolic outcomes. Moreover, it may be interesting to evaluate the quality (muscle density) or functional (muscle strength) outcomes in addition to both absolute (kg) and relative (%) values in future studies. The systematic review was prospectively registered at PROSPERO (registration number CRD42019124734; available at: http://www.crd.york.ac.uk/prospero [accessed: 05 April 2019]).

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Section: Resultsmentioning

confidence: 99%

Fat-free/lean body mass in children with insulin resistance or metabolic syndrome: a systematic review and meta-analysis

et al. 2022

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“…The potential effects of reverse causality, where dietary preferences such as high-fat 34 and lesser vitamin-containing foods 35 influenced by obesity status may affect serum vitamin A levels, cannot be discounted. Additionally, unaccounted confounding factors and the lack of data on visceral obesity or fatty liver disease among adolescents with normal BMI but increased visceral fat highlight the need for a cautious interpretation of the findings 36 , 37 . Meanwhile, this cross-sectional observational study data ranges from 1999 to 2006 years due to the unavailability of any recent data on vitamins in the NHANES database.…”

Section: Discussionmentioning

confidence: 99%

Association between serum vitamin A and body mass index in adolescents from NHANES 1999 to 2006

Su,

Patel,

Zhu

et al. 2024

Sci Rep

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Vitamin A plays a pivotal role in health, particularly in regulating fat metabolism. Despite its significance, research into the direct relationship between vitamin A levels and obesity, especially among adolescents, is sparse. This study aims to explore this association within the adolescent population in the United States. This cross-sectional study analyzed the National Health and Nutrition Examination Survey (NHANES) data from 1999 to 2006, with 8218 participants. The levels of vitamin A in the serum were determined based on utilizing high-performance liquid chromatography with photodiode array detection. The relationship between serum vitamin A concentrations and body mass index (BMI) was evaluated using weighted multiple linear regression models, incorporating subgroup analyses by sex and race/ethnicity to provide nuanced insights. A positive correlation was observed between serum vitamin A levels and BMI, with BMI increasing progressively across vitamin A quartiles (P < 0.001). Using the lowest quartile of serum vitamin A as a reference, the BMI of the highest quartile of serum vitamin A was 1.236 times higher (95% CI 0.888, 1.585). Subgroup analyses revealed that this positive association persisted across different genders and racial/ethnic groups (P < 0.001). Notably, smooth curve fitting and saturation threshold analysis unveiled an inverted U-shaped relationship between serum vitamin A and BMI among female adolescents, non-Hispanic Whites, Mexican Americans, and other races/ethnicities groups. Our study substantiates the association between serum vitamin A levels and the risk of obesity/overweight status in adolescents. The findings suggest the potential serum vitamin A is an early biomarker for identifying obesity risk, although further studies are needed to determine to clarify its role as a contributing factor to obesity. This study contributes to the understanding of nutritional influences on adolescent obesity, highlighting the need for targeted interventions based on serum biomarkers.

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2021 top 10 articles in the Arquivos Brasileiros de Cardiologia and the Revista Portuguesa de Cardiologia

Fontes‐Carvalho

Oliveira

Gonçalves-Teixeira

et al. 2022

Revista Portuguesa de Cardiologia

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Obesidade Visceral e Hipertensão Sistólica como Substratos da Disfunção Endotelial em Adolescentes Obesos

Cited by 5 publications

References 25 publications

Fat-free/lean body mass in children with insulin resistance or metabolic syndrome: a systematic review and meta-analysis

Fat-free/lean body mass in children with insulin resistance or metabolic syndrome: a systematic review and meta-analysis

Association between serum vitamin A and body mass index in adolescents from NHANES 1999 to 2006

2021 top 10 articles in the Arquivos Brasileiros de Cardiologia and the Revista Portuguesa de Cardiologia

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