Níveis Séricos do BDNF na Proteção Cardiovascular e em Resposta ao Exercício

Trombetta, Ivani C.; DeMoura, José Roberto; Alves, Cléber R.; Carbonari-Brito, Renato; Cepeda, Felipe X.; Lemos, José R.

doi:10.36660/abc.20190368

Cited by 13 publications

(3 citation statements)

References 64 publications

(86 reference statements)

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“…Peripherally, serum BDNF is found in platelets of the blood plasma and is formed by cells of the vascular endothelium and peripheral mononuclear cells. This protein has the capacity to freely cross the blood‐brain barrier in both directions, which increases its therapeutic potential 39 …”

Section: Discussionmentioning

confidence: 99%

“…This protein has the capacity to freely cross the blood-brain barrier in both directions, which increases its therapeutic potential. 39 Despite all the benefits attributed to BDNF, there is no consensus on its actions that mediate adaptive and maladaptive plasticity after SCI. 40 Studies suggest that BDNF exerts a therapeutic effect in SCI, exercising neuroprotective functions to prevent the apoptosis of oligodendrocytes and demyelination after the injury.…”

Section: Discussionmentioning

confidence: 99%

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Systemic vascular photobiomodulation accelerates the recovery of motor activity in rats following spinal cord injury

et al. 2023

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Objectives: Spinal cord injury (SCI) causes the discontinuity of the spinal canal, leading to functional and sensorial losses in areas below the injury, which are often irreversible. Photobiomodulation (PBM) can enhance the neuromuscular repair process, especially in cases of peripheral nerve injuries. However, there is little knowledge regarding the effects of this therapeutic modality on recovery following a SCI, especially the noninvasive systemic form denominated vascular PBM (VPBM). To analyze the effects of VPBM in the immediate, acute and intermediate phases following a compression-induced SCI on morphological aspects of neuromuscular tissue repair, functional recovery and the protein expression of brain-derived neurotrophic factor (BDNF). Methods: Wistar rats were divided into five groups: control, SCI, SCI + VPBM-Im (immediate administration of VPBM), SCI + VPBM-2h (VPBM administered 2 h after injury) and SCI + VPBM-14d (VPBM administered 14 days after injury). VPBM was administered in the region of the caudal vein/artery with low-level laser (AsGaAl, 780 nm, 80 J/cm², 40 mW for 80 s, totaling an energy of 3.2 J over a single point) for 14 consecutive days. During the analysis periods (1, 3, 7, 14, 21, 28 and 35 days after injury), functioning was evaluated using the Basso-Beattie-Bresnahan (BBB) index. At the end of each experimental period, blood samples were collected for the determination of the concentration of circulating BDNF using ELISA. Muscle tissue and nerve tissue samples were also extracted for morphological and histological analyses using H&E staining. Results: SCI + VPBM-Im and SCI + VPBM-2 h led to the recovery of motor function beginning on the 7th day after injury (p < 0.05), an increase in the crosssectional area (CSA) of the muscle fibers in the second week (p < 0.05) and an increase in muscle fiber diameter beginning on Day 14 (p < 0.05). Early irradiation had a greater effect on the reduction in the size of the cavity, with stabilization of the cavity found on Day 7 (p < 0.05). Considering the circulating BDNF levels, no changes was found during the experimental periods. Conclusion:The present results showed that VPBM was capable of modulating morphological and functional recovery following SCI, especially when administered early. The positive effects on functional recovery were demonstrated by the BBB index; the reestablishment of the structure of the muscle and nerve tissue was demonstrated by the preservation of CSA and diameter of muscle fiber and reduction in the area of the injury (cavity size) respectively. Thus, noninvasive VPBM may be an important component of treatment for spinal cord injuries.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Systemic vascular photobiomodulation accelerates the recovery of motor activity in rats following spinal cord injury

et al. 2023

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“…BDNF signals through the tropomyosin-related kinase B (TrkB) subsequently activating ERK1/2 and PI3K pathways [ 123 ]. Interestingly, BDNF has been postulated to be up-regulated by exercise and exhibit cardioprotective functions [ 124 , 125 ].…”

Section: Biomarkers Of Stress and The Biology Of Adversitymentioning

confidence: 99%

By what molecular mechanisms do social determinants impact cardiometabolic risk?

et al. 2023

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While it is well known from numerous epidemiologic investigations that social determinants (socioeconomic, environmental, and psychosocial factors exposed to over the life-course) can dramatically impact cardiovascular health, the molecular mechanisms by which social determinants lead to poor cardiometabolic outcomes are not well understood. This review comprehensively summarizes a variety of current topics surrounding the biological effects of adverse social determinants (i.e., the biology of adversity), linking translational and laboratory studies with epidemiologic findings. With a strong focus on the biological effects of chronic stress, we highlight an array of studies on molecular and immunological signaling in the context of social determinants of health (SDoH). The main topics covered include biomarkers of sympathetic nervous system and hypothalamic–pituitary–adrenal axis activation, and the role of inflammation in the biology of adversity focusing on glucocorticoid resistance and key inflammatory cytokines linked to psychosocial and environmental stressors (PSES). We then further discuss the effect of SDoH on immune cell distribution and characterization by subset, receptor expression, and function. Lastly, we describe epigenetic regulation of the chronic stress response and effects of SDoH on telomere length and aging. Ultimately, we highlight critical knowledge gaps for future research as we strive to develop more targeted interventions that account for SDoH to improve cardiometabolic health for at-risk, vulnerable populations.

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Ginsenoside Rh2 administration produces crucial antidepressant‐like effects in a CUMS‐induced mice model of depression

Shi

Liu

et al. 2022

Brain and Behavior

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Introduction The most striking feature of depression is sadness and a loss of interest in activities, which represents a major cause of disability globally. Therefore, it is necessary to identify novel antidepressants for clinical practice. Ginsenoside Rh2 (Rh2) is one of the major bioactive ginsenosides that can be extracted from Panax ginseng and has been demonstrated to improve both memory and learning. The purpose of this study was to provide broad insight into the mechanisms underlying depression and gain greater insights into antidepressant therapy. Methods In this study, we first established an effective and feasible depression animal model of chronic unpredictable mild stress (CUMS) and behavioral testing was evaluated by the forced swim test (FST), the tail suspension test (TST) and the sucrose preference test. Following pretreatment with Rh2 (10 and 20 mg/kg), the immobility time of mice was reduced without affecting locomotor activity in both the FST and TST. Western blotting and immunofluorescence were used to investigate the activation of the hippocampal BDNF signaling pathway and hippocampal neurogenesis. Results Different concentrations of Rh2 significantly reduced depressive‐like symptoms in CUMS‐induced mice and downregulated the effects of the BDNF signaling cascade and neurogenesis in the hippocampus. Furthermore, the administration of K252a completely prevented the antidepressant‐like activity of Rh2 in mice. Conclusion The results indicated that Rh2 possesses the antidepression action via the positive regulation of the BDNF‐TrkB pathway.

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Níveis Séricos do BDNF na Proteção Cardiovascular e em Resposta ao Exercício

Cited by 13 publications

References 64 publications

Systemic vascular photobiomodulation accelerates the recovery of motor activity in rats following spinal cord injury

Systemic vascular photobiomodulation accelerates the recovery of motor activity in rats following spinal cord injury

By what molecular mechanisms do social determinants impact cardiometabolic risk?

Ginsenoside Rh2 administration produces crucial antidepressant‐like effects in a CUMS‐induced mice model of depression

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