Estudo da Reatividade Microvascular em Pacientes Hipertensos com Adiposidade Corporal Elevada

d'El-Rei, Jenifer; Cunha, Michelle Rabello; Mattos, Samanta de Souza; Marques, Bianca Cristina; MENEZES, VANESSA M.; Cunha, Ana Rosa; França, Érica Monteiro; Oigman, Wille; Neves, Mário Fritsch

doi:10.36660/abc.20190364

Cited by 4 publications

(1 citation statement)

References 22 publications

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“…A study performed in hypertensive patients where microvascular reactivity was analyzed with Laser Speckle Contrast Image and pulse wave showed that higher body adiposity was associated with lower microvascular reactivity [38], similar to our study. The authors attribute the negative effects of obesity to the inflammation that vascular adipose tissue generates, increasing endothelial dysfunction by an increase in the secretion of vasoconstriction factors and proinflammatory adipokines that cause vascular inflammation and decrease endothelial activation [39].…”

Section: Hyperemia Reactive Responsesupporting

confidence: 89%

Association between Fractional Oxygen Extraction from Resting Quadriceps Muscle and Body Composition in Healthy Men

Yáñez-Sepúlveda,

Olivares-Arancibia,

Cortés-Roco

et al. 2023

JFMK

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This study aimed to associate body composition with fractional oxygen extraction at rest in healthy adult men. Fourteen healthy adults (26.93 ± 2.49 years) from Chile participated. Body composition was assessed with octopole bioimpedance, and resting muscle oxygenation was evaluated in the vastus lateralis quadriceps with near-infrared spectroscopy (NIRS) during a vascular occlusion test, analyzing the muscleVO2, resaturation velocity during reactive hyperemia via the muscle saturation index (%TSI), and the area above the curve of HHb (AACrep). It was observed that the total and segmented fat mass are associated with lower reoxygenation velocities during hyperemia (p = 0.008; β = 0.678: p = 0.002; β = 0.751), and that the total and segmented skeletal muscle mass are associated with higher reoxygenation velocities during hyperemia (p = 0.020; β = −0.614: p = 0.027; β = −0.587). It was also observed that the total and segmented fat mass were associated with a higher area above the curve of HHb (AACrep) during hyperemia (p = 0.007; β = 0.692: p = 0.037; β = 0.564), and that total and segmented skeletal muscle mass was associated with a lower area above the curve of HHb (AACrep) during hyperemia (p = 0.007; β = −0.703: p = 0.017; β = −0.632). We concluded that fat mass is associated with lower resaturation rates and lower resting fractional O2 extraction levels. In contrast, skeletal muscle mass is associated with higher resaturation rates and fractional O2 extraction during reactive hyperemia. The AACrep may be relevant in the evaluation of vascular adaptations to exercise and metabolic health.

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Section: Hyperemia Reactive Responsesupporting

confidence: 89%