Relação entre Periodontite, Polimorfismos Genéticos e Doença Arterial Coronariana no Sul do Brasil

Rocha, Luiz Otávio Savassi; Rocha, Eduarda; Succi, Guilherme de Menezes; Brito, Rui Barbosa de

doi:10.36660/abc.20180296

Cited by 3 publications

(1 citation statement)

References 27 publications

(40 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CAD is responsible for numerous acute coronary syndromes and is the main cause of death in the Western hemisphere. 1 CAD is a multifactorial illness that is affected by both acquired and inherited factors. Certain risk factors for CAD are modifiable, such as lifestyle changes and medication management.…”

Section: Introductionmentioning

confidence: 99%

Genetic Association of rs10757278 on Chromosome 9p21 and Coronary Artery Disease in a Saudi Population

Bogari

Dannoun

Athar

et al. 2021

IJGM

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Genetic Association of rs10757278 on Chromosome 9p21 and Coronary Artery Disease in a Saudi Population

Bogari

Dannoun

Athar

et al. 2021

IJGM

View full text Add to dashboard Cite

Automatic text-mining as an unbiased approach to uncover molecular associations between periodontitis and coronary artery disease

et al. 2021

View full text Add to dashboard Cite

Analysis of the Effects of IL-6 -572 C/G, CRP -757 A/G, and CRP -717 T/C Gene Polymorphisms; IL-6 Levels; and CRP Levels on Chronic Periodontitis in Coronary Artery Disease in Indonesia

Sitompul

Pikir

Aryati

et al. 2023

Genes

View full text Add to dashboard Cite

Interleukin 6 (IL-6) and C-Reactive Protein (CRP) play an important role in chronic periodontitis with coronary artery disease (CAD). Genetic factors can affect a person’s risk of CAD, which affects one-third of the population. This study investigated the role of IL-6 -572 C/G, CRP -757 A/G, and CRP -717 T/C gene polymorphisms. IL-6 and CRP levels on the severity of periodontitis in CAD in Indonesia were also evaluated. This case-control study was conducted with mild and moderate–severe chronic periodontitis groups. A path analysis test was conducted with Smart PLS with a 95% confidence interval to determine the significant variable for chronic periodontitis. Our study revealed that the effects of IL-6 -572 C/G, CRP -757 A/G, and CRP -717 T/C gene polymorphisms on IL-6 levels and CRP levels were not significant. IL-6 and CRP levels were not significantly different between the two groups. We found that IL-6 levels had a significant effect on CRP levels in periodontitis patients with CAD (path coefficient 0.322, p = 0.003). IL-6 -572 C/G, CRP -757 A/G, and CRP -717 T/C gene polymorphisms had no effect on the severity of chronic periodontitis in CAD patients in the Indonesian population. We also observed no apparent effects of the influence of gene polymorphisms in IL-6 -572 C/G, CRP -757 A/G, and CRP -717 T/C genes. Although the IL-6 and CRP levels were not significantly different between the two groups, IL-6 levels affected CRP levels in periodontitis patients with CAD.

show abstract

Relação entre Periodontite, Polimorfismos Genéticos e Doença Arterial Coronariana no Sul do Brasil

Cited by 3 publications

References 27 publications

Genetic Association of rs10757278 on Chromosome 9p21 and Coronary Artery Disease in a Saudi Population

Genetic Association of rs10757278 on Chromosome 9p21 and Coronary Artery Disease in a Saudi Population

Automatic text-mining as an unbiased approach to uncover molecular associations between periodontitis and coronary artery disease

Analysis of the Effects of IL-6 -572 C/G, CRP -757 A/G, and CRP -717 T/C Gene Polymorphisms; IL-6 Levels; and CRP Levels on Chronic Periodontitis in Coronary Artery Disease in Indonesia

Contact Info

Product

Resources

About