The role of IL10 and IL17 gene polymorphisms in treatment response in children and adolescents with severe asthma
Mariana Isadora Ribeiro Vieira1,
Mônica Versiani Nunes Pinheiro de Queiroz3,
Maria Borges Rabelo de Santana2
et al.
Abstract:Objective: To determine whether polymorphisms of the IL10 and IL17 genes are associated with severe asthma control and bronchodilator reversibility in children and adolescents with severe asthma. Methods: This was a cross-sectional study, nested within a prospective cohort study of patients with severe asthma. Two outcomes were evaluated: asthma control and bronchodilator reversibility. We extracted DNA from peripheral blood and genotyped three single nucleotide polymorphisms: rs3819024 and rs2275913 in the IL… Show more
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