Small airway disease: when the “silent zone” speaks up

Neder, J. Alberto; Berton, Danilo Cortozi; O'Donnell, Denis E

doi:10.36416/1806-3756/e20220414

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2023

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“… 3 There is no uniformly accepted algorithm for the investigation of DUO ( Figure 1 ). The value of more sophisticated pulmonary function tests-particularly those assessing the small airways 4 -remains elusive. Cardiopulmonary exercise testing is frequently useful to rule out major cardiopulmonary disease, showing the negative consequences of obesity, simple deconditioning, and, occasionally, hyperventilation/dysfunctional breathing.…”

Section: Overviewmentioning

confidence: 99%

The pulmonary function laboratory in the investigation of dyspnea of unknown origin

2023

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Chronic dyspnea (i.e., dyspnea for at least 3 months) negatively impacts the health-related quality of life of ~10% of the general population. In a sizable fraction of these individuals, the underlying cause remains unclear after detailed clinical assessment, basic pulmonary function tests, and chest imaging, characterizing dyspnea of unknown origin (DUO). The “lung doctor” is frequently called to assess these patients for diagnostic clarification, an endeavor fraught with complexities in most circumstances.

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confidence: 99%