Sleep health and the circadian rest-activity pattern four months after COVID-19

Henríquez-Beltrán, Mario; Labarca, Gonzalo; Cigarroa, Igor; Enos, Daniel; Lastra, Jaime; Nova-Lamperti, Estefanía; Targa, Adriano; Barbé, Ferrán

doi:10.36416/1806-3756/e20210398

Cited by 11 publications

(5 citation statements)

References 42 publications

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“…COVID-19 patients tend to experience fear and anxiety about social isolation procedures, as well as mandatory lockdowns in the acute phase, leading to an increased incidence of sleep disturbances in the population ( 51 – 53 ). A study reported a higher prevalence of difficulty falling asleep, staying asleep, and getting up early in patients with moderately severe COVID-19 infection, whereas difficulty staying asleep and waking up earlier was experienced in patients with more severe disease ( 54 ). Another study showing that diabetes mellitus was independently associated with sleep disturbances among patients with post COVID-19 conditions showed that the presence of chronic illnesses can also have an impact on the persistence of sleep disturbance ( 16 ).…”

Section: Discussionmentioning

confidence: 99%

Sleep disturbance in post COVID-19 conditions: Prevalence and quality of life

et al. 2023

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Post COVID-19 conditions are complaints and symptoms in patients with a history of probable or confirmed COVID-19 after 3 months of the onset of COVID-19 and last at least 2 months. About 10–20% of people may experience post COVID-19 conditions, one of which is sleep disturbance. There is a wide range of prevalence of sleep disturbances from 6% to more than 70%. An online survey of the post COVID-19 conditions in various countries showed that 78.58% of subjects had sleep disturbances, including insomnia, sleep-disordered breathing, central disorders of hypersomnolence, circadian rhythm sleep-wake disorders, parasomnias, and sleep-related movement disorders. Sleep disturbance can be found starting from 2 weeks until 48 weeks or more after discharge or after having a negative COVID-19 test results. Women aged < 50 years old with severe COVID-19 infection reported a worse outcome. Several mechanisms may cause sleep disturbance in post COVID-19 condition, namely persistent viral infection and inflammation, immunity dysregulation, and mitochondrial dysfunction. Several studies discovered sleep disturbance was a major problem that affected different domains of QoL in post COVID-19 conditions. Significant correlation was found between several dimensions of SF-36 with moderate-to-severe insomnia in post COVID-19 conditions. Therefore, sleep disturbance is a major problem in post COVID-19 conditions and may affect patients' QoL, and the existence of sleep disturbance should be a concern in post COVID-19 conditions period. Further research is required to determine the prevalence based on agreed definition as well as methods to assess this condition and its impact on QoL.

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Section: Discussionmentioning

confidence: 99%

Sleep disturbance in post COVID-19 conditions: Prevalence and quality of life

et al. 2023

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“…While sleep disturbances are common and more recently have been attributed to societal restrictions during the COVID-19 pandemic, a systematic review and meta-analysis revealed that over 50% of people who had been infected with SARS-CoV-2 suffered with sleep disturbances ( 142 ). One small study demonstrated significant sleep impairment four months after having COVID-19 with an increased prevalence among those with obstructive sleep apnea ( 143 ). Chronotherapy is an emerging therapeutic in pulmonary and sleep medicine as we understand how the disruption of circadian rhythm affects cells of virally infected organs such as the lung and the immune system ( 144 ).…”

Section: Current State Of Long Covid Management and Potential Therape...mentioning

confidence: 99%

Therapeutic trials for long COVID-19: A call to action from the interventions taskforce of the RECOVER initiative

et al. 2023

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Although most individuals recover from acute SARS-CoV-2 infection, a significant number continue to suffer from Post-Acute Sequelae of SARS-CoV-2 (PASC), including the unexplained symptoms that are frequently referred to as long COVID, which could last for weeks, months, or even years after the acute phase of illness. The National Institutes of Health is currently funding large multi-center research programs as part of its Researching COVID to Enhance Recover (RECOVER) initiative to understand why some individuals do not recover fully from COVID-19. Several ongoing pathobiology studies have provided clues to potential mechanisms contributing to this condition. These include persistence of SARS-CoV-2 antigen and/or genetic material, immune dysregulation, reactivation of other latent viral infections, microvascular dysfunction, and gut dysbiosis, among others. Although our understanding of the causes of long COVID remains incomplete, these early pathophysiologic studies suggest biological pathways that could be targeted in therapeutic trials that aim to ameliorate symptoms. Repurposed medicines and novel therapeutics deserve formal testing in clinical trial settings prior to adoption. While we endorse clinical trials, especially those that prioritize inclusion of the diverse populations most affected by COVID-19 and long COVID, we discourage off-label experimentation in uncontrolled and/or unsupervised settings. Here, we review ongoing, planned, and potential future therapeutic interventions for long COVID based on the current understanding of the pathobiological processes underlying this condition. We focus on clinical, pharmacological, and feasibility data, with the goal of informing future interventional research studies.

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“…The prevalences of e.g., exercise intolerance, fatigue, joint and muscle pain, and mental disorders are high with 60–87% of patients still suffering from these symptoms. Previous research reported a poor sleep quality of post-COVID patients, too [ 53 , 101 , 102 ]. Jarosch, et al [ 53 ] examined sleep quality of post-COVID patients with polysomnography and compared the results with healthy controls.…”

Section: Discussionmentioning

confidence: 99%

Device-assessed physical activity and sleep quality of post-COVID patients undergoing a rehabilitation program

Poppele,

Ottiger,

Stegbauer

et al. 2024

BMC Sports Sci Med Rehabil

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Background An infection with SARS-CoV-2 can lead to persistent symptoms more than three months after the acute infection and has also an impact on patients’ physical activity behaviour and sleep quality. There is evidence, that inpatient post-COVID rehabilitation can improve physical capacity and mental health impairments, but less is known about the change in physical behaviour and sleep quality. Methods This longitudinal observational study used accelerometery to assess the level of physical activity and sleep quality before and after an inpatient rehabilitation program. The study sample consists of 100 post-COVID patients who acquired COVID-19 in the workplace. Group differences related to sex, age, COVID-19 severity, and pre-existing diseases were also analysed. Results Level of physical activity and sleep quality didn’t increase after rehabilitation. Overall, there is a high extent of inactivity time and poor sleep quality at both measurement points. Regarding group differences, male patients showed a significantly higher inactivity time before rehabilitation, and younger patients (< 55 years) spend significant more time in vigorous physical activity than older patients. Post-COVID patients with pre-existing cardiovascular, respiratory, and metabolic disease show slightly less physical activity than post-COVID patients without these comorbidities. Female patients and younger patients showed better sleep quality in some sleep parameters at both measurement points. However, no differences could be detected related to COVID-19 severity. Conclusions Ongoing strategies should be implemented to address the high amount of inactivity time and the poor sleep quality in post-COVID patients.

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Sleep health and the circadian rest-activity pattern four months after COVID-19

Cited by 11 publications

References 42 publications

Sleep disturbance in post COVID-19 conditions: Prevalence and quality of life

Sleep disturbance in post COVID-19 conditions: Prevalence and quality of life

Therapeutic trials for long COVID-19: A call to action from the interventions taskforce of the RECOVER initiative

Device-assessed physical activity and sleep quality of post-COVID patients undergoing a rehabilitation program

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