Reference values for spirometry in Brazilian children

Jones, Marcus Herbert; Vidal, Paula; Lanza, Fernanda Cordoba; Silva, Danielle Corrêa França de Melo Franco; Pitrez, Paulo Márcio; Olmedo, Ana Paula Bigliardi de Freitas; Burity, Edjane Figueiredo; Schisler, K L.; Pinto, Leonardo Araújo; Winck, Aline Dill; Souza, Edna Lúcia; Oliveira, Anick Augustin; Ribeiro, Maria Ângela Gonçalves de Oliveira; Torres, Lidia Alice Gomes Monteiro Marin; March, Maria de Fátima Bazhuni Pombo; Pulmonar, Grupo de Trabalho em Função

doi:10.36416/1806-3756/e20190138

Cited by 12 publications

(9 citation statements)

References 18 publications

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“…Tests were repeated as far as the obtaining of repeatable values, not exceeding 8 attempts. Both the flow-volume and volume-time curves as the results were primarily analyzed by the researchers during the test; those that did not reach acceptance and reproducibility criteria were excluded at the moment of sampling [ 12 ].…”

Section: Methodsmentioning

confidence: 99%

Shorter telomeres in children with severe asthma, an indicative of accelerated aging

Barbé-Tuana

Grün

Pierdoná

et al. 2021

Aging

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Severe therapy-resistant asthma (STRA) is closely associated with distinct clinical and inflammatory pheno-endotypes, which may contribute to the development of age-related comorbidities. Evidence has demonstrated a contribution of accelerated telomere shortening on the poor prognosis of respiratory diseases in adults. Eotaxin-1 (CCL11) is an important chemokine for eosinophilic recruitment and the progression of asthma. In the last years has also been proposed as an age-promoting factor. This study aimed to investigate the association of relative telomere length (rTL) and eotaxin-1 in asthmatic children. Children aged 8-14 years (n=267) were classified as healthy control (HC, n=126), mild asthma (MA, n=124) or severe therapy-resistant asthma (STRA, n=17). rTL was performed by qPCR from peripheral blood. Eotaxin-1 was quantified by ELISA from fresh-frozen plasma. STRA had shorter telomeres compared to HC ( p =0.02) and MA ( p =0.006). Eotaxin-1 levels were up-regulated in STRA [median; IQR25-75)] [(1,190 pg/mL; 108–2,510)] compared to MA [(638 pg/mL; 134–1,460)] ( p =0.03) or HC [(627 pg/mL; 108–1,750)] ( p <0.01). Additionally, shorter telomeres were inversely correlated with eotaxin-1 levels in STRA (r=-0.6, p =0.013). Our results suggest that short telomeres and up-regulated eotaxin-1, features of accelerated aging, could prematurely contribute to a senescent phenotype increasing the risk for early development of age-related diseases in asthma.

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Section: Methodsmentioning

confidence: 99%

Shorter telomeres in children with severe asthma, an indicative of accelerated aging

Barbé-Tuana

Grün

Pierdoná

et al. 2021

Aging

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“…A study with 1.990 healthy Brazilian children identified that most were within the predicted value in the FEV 1 and FVC parameters. 30 …”

Section: Discussionmentioning

confidence: 99%

Respiratory system parameters in children with low severity cystic fibrosis: is there early involvement in relation to healthy peers?

Ducati,

Cardoso,

Ferrazeane

et al. 2024

Rev. paul. pediatr.

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Objective: To compare and analyze pulmonary function and respiratory mechanics parameters between healthy children and children with cystic fibrosis. Methods: This cross-sectional analytical study included healthy children (HSG) and children with cystic fibrosis (CFG), aged 6–13 years, from teaching institutions and a reference center for cystic fibrosis in Florianópolis/SC, Brazil. The patients were paired by age and sex. Initially, an anthropometric evaluation was undertaken to pair the sample characteristics in both groups; the medical records of CFG were consulted for bacterial colonization, genotype, and disease severity (Schwachman-Doershuk Score — SDS) data. Spirometry and impulse oscillometry were used to assess pulmonary function. Results: In total, 110 children were included, 55 in each group. In the CFG group, 58.2% were classified as excellent by SDS, 49.1% showed the ΔF508 heterozygotic genotype, and 67.3% were colonized by some pathogens. Statistical analysis revealed significant differences between both groups (p<0.05) in most pulmonary function parameters and respiratory mechanics. Conclusions: Children with cystic fibrosis showed obstructive ventilatory disorders and compromised peripheral airways compared with healthy children. These findings reinforce the early changes in pulmonary function and mechanics associated with this disease.

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“…For the calculation, the factors considered are sex, age, height, and skin color. 11 Categorical variables were presented in absolute and relative frequencies. The measures of central tendency and dispersion were presented as mean and standard deviation or median and interquartile range.…”

Section: Methodsmentioning

confidence: 99%

Respiratory function of children and adolescents with osteogenesis imperfecta: respiratory muscle strength, forced vital capacity, and peak expiratory flow

Carvalho

Regis

Faiçal

et al. 2023

Rev. paul. pediatr.

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Objective: This study aims to evaluate the respiratory function of children and adolescents with osteogenesis imperfecta (OI) followed up at a referral center. Methods: A cross-sectional study was conducted with a non-probabilistic sample. Manovacuometry was performed with the measurement of maximal inspiratory pressure (MIP) and maximal expiratory pressure (MEP), and in addition, peak expiratory flow (PEF) and ventilometry were performed to measure forced vital capacity (FVC). Results: In total, 23 individuals were evaluated, with a mean age of 11.6±3.4 years, 56.5% of whom were females. Regarding the classification of OI, 56.5% of the sample belonged to type IV, 30.5% to type III, and 13% to type I. The mean MIP was 64.4% of the predicted, and the mean MEP was 56.2% of the predicted. Overall, the mean PEF was 213.9 L/min, but only 140.6 L/min in the OI type III group. Median FVC was 1.9 L, corresponding to 110% of the predicted. Conclusions: Respiratory function of the study subjects was altered, with respiratory muscle strength values lower than expected in the whole sample, and peak expiratory flow was significantly reduced in the OI type III group.

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Reference values for spirometry in Brazilian children

Cited by 12 publications

References 18 publications

Shorter telomeres in children with severe asthma, an indicative of accelerated aging

Shorter telomeres in children with severe asthma, an indicative of accelerated aging

Respiratory system parameters in children with low severity cystic fibrosis: is there early involvement in relation to healthy peers?

Respiratory function of children and adolescents with osteogenesis imperfecta: respiratory muscle strength, forced vital capacity, and peak expiratory flow

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