Mesothelium and Malignant Mesothelioma

Hiriart, Emilye; Deepe, Raymond N.; Wessels, Andy

doi:10.3390/jdb7020007

Cited by 40 publications

(22 citation statements)

References 192 publications

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“…The formation of the epicardium is initiated when cells from the proepicardium attach to the myocardial surface of the looping heart and spread out to form an epicardial sheet. The proepicardium is a conglomerate of mesothelially derived cells that form a cauliflower-shaped structure at the interface between liver and sinus venosus [ 39 , 40 , 41 , 42 , 43 ]. A subset of epicardial cells will undergo an epicardial-to-mesenchymal transformation (epiMT), leading to the formation of epicardially derived cells (EPDCs) [ 44 ].…”

Section: Cardiac Mesenchyme and Its Contribution To Cardiac Septatmentioning

confidence: 99%

The Mesenchymal Cap of the Atrial Septum and Atrial and Atrioventricular Septation

Deepe

Fitzgerald

Wolters

et al. 2020

JCDD

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In this publication, dedicated to Professor Robert H. Anderson and his contributions to the field of cardiac development, anatomy, and congenital heart disease, we will review some of our earlier collaborative studies. The focus of this paper is on our work on the development of the atrioventricular mesenchymal complex, studies in which Professor Anderson has played a significant role. We will revisit a number of events relevant to atrial and atrioventricular septation and present new data on the development of the mesenchymal cap of the atrial septum, a component of the atrioventricular mesenchymal complex which, thus far, has received only moderate attention.

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Section: Cardiac Mesenchyme and Its Contribution To Cardiac Septatmentioning

confidence: 99%

The Mesenchymal Cap of the Atrial Septum and Atrial and Atrioventricular Septation

Deepe

Fitzgerald

Wolters

et al. 2020

JCDD

Self Cite

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“…Malignant mesothelioma (MM) is a very aggressive cancer of the serous membranes lining the body cavities: approximately 70-80% of MMs develop in the pleura, 20% in the peritoneum, and a minority affects the pericardium and tunica vaginalis [1]. The main risk factor for MM is exposure to asbestos [2,3], which is implicated in~80% of cases [1]. Although the use of asbestos has been banned in many countries, MM burden is still substantial, with over 30,000 cases and over 25,000 deaths worldwide in 2018 [4].…”

Section: Introductionmentioning

confidence: 99%

Targeting SRC Family Kinases in Mesothelioma: Time to Upgrade

Indovina

Forte

Pentimalli

et al. 2020

Cancers

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Malignant mesothelioma (MM) is a deadly tumor mainly caused by exposure to asbestos. Unfortunately, no current treatment is able to change significantly the natural history of the disease, which has a poor prognosis in the majority of patients. The non-receptor tyrosine kinase SRC and other SRC family kinase (SFK) members are frequently hyperactivated in many cancer types, including MM. Several works have indeed suggested that SFKs underlie MM cell proliferation, survival, motility, and invasion, overall affecting multiple oncogenic pathways. Consistently, SFK inhibitors effectively counteracted MM cancerous features at the preclinical level. Dasatinib, a multi-kinase inhibitor targeting SFKs, was also assessed in clinical trials either as second-line treatment for patients with unresectable MM or, more recently, as a neoadjuvant agent in patients with resectable MM. Here, we provide an overview of the molecular mechanisms implicating SFKs in MM progression and discuss possible strategies for a more successful clinical application of SFK inhibitors. Our aim is to stimulate discussion and further consideration of these agents in better designed preclinical and clinical studies to make the most of another class of powerful antitumoral drugs, which too often are lost in translation when applied to MM.

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“…Mesothelioma is the neoplastic transformation of the mesothelial cells that line the serosal surfaces of the body, including the pleura, peritoneum, pericardium and tunica vaginalis 1. Asbestos inhalation is its greatest risk factor, which likely explains why mesothelioma is most frequently pleural in origin.…”

Section: Introductionmentioning

confidence: 99%

Diffuse epithelioid malignant mesothelioma of the pleura presenting as a hydropneumothorax and vertebral body invasion

et al. 2020

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Malignant mesothelioma is an uncommon form of neoplastic transformation of the mesothelial cells that line the serosal surfaces of the body. It most commonly affects the pleura and is often associated with pleural effusions and pleural-based masses. The annual incidence in the United States is only 3300 cases, representing less than 0.3% of all cancers worldwide, although this is likely underestimated. We present a case of diffuse epithelioid malignant pleural mesothelioma in a patient with remote, short-term asbestos exposure complicated by recurrent left-sided hydropneumothoraces and pleural-based invasion of the T12 vertebral body, which represent two rare coexisting complications. This case illustrates the importance of maintaining a broad differential for hydropneumothorax, particularly as the risk factors may be decades removed and the degree of asbestos exposure to induce a malignant mesothelioma may be smaller than has been traditionally thought.

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Mesothelium and Malignant Mesothelioma

Cited by 40 publications

References 192 publications

The Mesenchymal Cap of the Atrial Septum and Atrial and Atrioventricular Septation

The Mesenchymal Cap of the Atrial Septum and Atrial and Atrioventricular Septation

Targeting SRC Family Kinases in Mesothelioma: Time to Upgrade

Diffuse epithelioid malignant mesothelioma of the pleura presenting as a hydropneumothorax and vertebral body invasion

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