Potential Role of Cannabidiol on Sports Recovery: A Narrative Review

Rojas-Valverde, Daniel

doi:10.3389/fphys.2021.722550

Cited by 14 publications

(8 citation statements)

References 50 publications

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“…The present finding of increased liver CBD provides a theoretical basis to support recent proposals that CBD could exert antioxidant and anti-inflammatory effects in the liver [ 7 , 41 ]. Elevated skeletal muscle CBD could affect contractility, antioxidant protection and exercise recovery [ 42 , 43 ]; which would have implications for training and sports performance [ 44 ]. It is important for future studies on the potential benefits of elevated CBD in liver, muscle and adipose employ relevant biomarkers and clinical endpoints.…”

Section: Discussionmentioning

confidence: 99%

Cannabidiol (CBD) Dosing: Plasma Pharmacokinetics and Effects on Accumulation in Skeletal Muscle, Liver and Adipose Tissue

Child

Tallon²

2022

Nutrients

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Oral cannabidiol (CBD) consumption is widespread in North America and Europe, as it has analgesic, neuroprotective and antitumor effects. Although oral CBD consumption in humans affords beneficial effects in epileptic and inflammatory states, its pharmacokinetics and subsequent uptake into tissue are largely unknown. This study investigated plasma pharmacokinetics and accumulation of CBD in gastrocnemius muscle, liver and adipose tissue in adult rats following oral gavage. CBD was fed relative to body mass at 0 (control), 30, 115, or 230 mg/Kg/day for 28 days; with 6 males and 6 females per dosing group. Pharmacokinetics were assessed on day 1 and day 28 in the group receiving CBD at 115 mg/Kg/day. The rise in tissue CBD was closely related to specific pharmacokinetic parameters, and adipose tissue levels were ~10 to ~100 fold greater than liver or muscle. Tissue CBD levels were moderately correlated between adipose and muscle, and adipose and liver, but were highly correlated for liver and muscle. CBD feeding resulted in several gender-specific effects, including changes in pharmacokinetics, relationships between pharmacokinetic parameters and tissue CBD and differences in tissue CBD levels. CBD accumulation in mammalian tissues has the potential to influence receptor binding and metabolism; therefore, the present findings may have relevance for developing oral dosing regimens.

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Section: Discussionmentioning

confidence: 99%

Cannabidiol (CBD) Dosing: Plasma Pharmacokinetics and Effects on Accumulation in Skeletal Muscle, Liver and Adipose Tissue

Child

Tallon²

2022

Nutrients

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“…Penelitian lain juga menyebutkan hipotesis teori yang disebut dengan physchomotor theory, disebutkan bahwa ada hubungan antara latihan dan juga kontrol pikiran, dimana seseorang mampu melakukan gerak tubuh yang sesuai dengan apa yang diinginkan (Tan, 2007), atau juga bisa disebut dengan kecerdasan kinestetik tubuh (Gardner & Hatch, 1989), kemampuan gerak dari pemikiran (Fischer & Bidell, 1998). Selain itu, ketika seseorang melakukan latihan olahraga, terdapat juga efek berupa penenang atau anti depresan yang mampu lebih meningkatkan performa kinerja seseorang tersebut (Rojas-Valverde, 2021). Bahkan penelitian yang dilakukan oleh Tan (Tan, 2007) mengemukakan bahwa dalam kemampuan kognitif, kemampuan gerak seseorang dapat menempatkan posisi yang penting.…”

Section: Pembahasanunclassified

Analisis biomotor kecepatan reaksi pada pemain bola voli kelas khusus olahraga Daerah Istimewa Yogyakarta

Fauzi

Dwihandaka

Pamungkas

et al. 2021

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Empat puluh tiga pemain yang berlatih di Sekolah Menengah Atas Kelas Khusus Olahraga Daerah Istimewa Yogyakarta berpartisipasi dalam penelitian ini. Pengambilan data telah disetujui oleh pelatih dari sekolah tersebut. Para pemain dalam kondisi sehat saat melakukan tes. Sebelum melakukan tes, pemain mendapatkan penjelasan tentang penelitian ini. Instrumen yang dipergunakan dalam pengambilan data untuk mengetahui kecepatan reaksi seseorang diukur dengan menggunakan tes whole body reaction. Setelah data diperoleh kemudian dianalisis dengan membandingkan data dengan norma instrument tes whole body reaction. Kemudian setelah itu dicari prosentase kategori kecepatan reaksi yang dimiliki oleh pemain Kelas Khusus Olahraga Bola Voli di D.I. Yogyakarta. Dari hasil pengukuran yang dilakukan ditemukan bahwa terdapat 30% dari pemain bola voli di Kelas Khusus Olahraga Yogyakarta memiliki kecepatan reaksi yang masuk dalam kategori bagus sekali, 63% termasuk dalam kategori bagus, dan 7% dalam kategori cukup. Hasil ini tentu tidak akan terlepas dari banyak faktor yang mempengaruhi kecepatan reaksi yang dimiliki oleh seseorang.Biomotor Analysis of Reaction Speed in Players of Special Class volleyball in Yogyakarta Special Region AbstractForty-three players who trained at the Yogyakarta Special Sports Class High School participated in the study. The data retrieval has been approved by the school's trainer. The players are in good health when conducting tests. Before conducting the test, the player gets an explanation about this study. The instrument used in data retrieval to determine the speed of a person's reaction is measured using the Whole Body Reaction test. After the data is obtained then analyzed by comparing the data with the instrument norms of whole body reaction test. Then after that sought percentage of reaction speed category owned by players special class volleyball sports in D.I. Yogyakarta. From the results of the measurements, it was found that 30% of volleyball players in Yogyakarta Sports Special Class had reaction speed that falls into the category of very good, 63% belongs to the good category, and 7% in the category of enough. These results will certainly not be separated from many factors that affect the speed of reaction that a person has.

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“…Due to the recent elimination of CBD from the list of prohibited substances by federations and international institutions of sports in 2018, the use of CBD among athletes is becoming more common, making this a particularly relevant population of study (Rojas-Valverde 2021 ). It has been proposed that CBD could improve the efficiency of recovery during and after exercise in athletes, and athletes specifically desire to use topical CBD in order to limit systemic exposure, which is perceived to further increase safety.…”

Section: Introductionmentioning

confidence: 99%

Topical cannabidiol is well tolerated in individuals with a history of elite physical performance and chronic lower extremity pain

et al. 2023

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Introduction Cannabidiol (CBD) is a potential therapeutic for pain management. Yet, there exists a dearth of studies of its tolerability and efficacy, especially in special populations. Former elite athletes are a special population both susceptible to chronic pain and also highly trained and attuned to assess medication tolerability concerns. The purpose of the present open-label pilot study was to assess the tolerability of CBD in this population. Materials and methods Retrospective analysis was conducted in deidentified data from 20 individuals who were all previously professional athletes in US/American football, track and field, or basketball, with careers ranging from 4 to 10 years. Participants received topical CBD (10 mg twice daily by controlled dispenser) for chronic pain resulting from acute lower extremity injuries. Assessments of tolerability and secondary analyses of pain, pain-related disability, and activities of daily living were collected by self-report over the 6-week study period. Data were analyzed by descriptive statistics, pairwise t-test, and linear regression. Results Seventy percent of participants completed the study. Of the individuals who completed the study, 50% reported minor adverse effects, none of which required medical attention, and 50% did not report any adverse effects. The mostly commonly reported effects were skin dryness (43% of study completers) and skin rash (21% of study completers), which rapidly resolved. There was a significant improvement in self-reported pain levels (intake mean 3.5 ± 0.29; exit mean 1.7 ± 0.23; P < 0.001) and pain-related disability, including family and home responsibilities, life support activities, occupational activities, recreational activities, self-care, sexual function, and social activities (all P < 0.001). Discussion To the best of our knowledge, this is the first study to assess CBD treatment in elite athletes, who are disproportionally susceptible to disabling injuries. Topical administration of CBD was tolerated well by this population and resulted in only minor adverse effects. As elite athletes are trained and attuned to assess their own bodies due to their professional lives, this population is likely to detect tolerability concerns. However, this study was limited to a convenience sample and self-reported data. These pilot findings warrant further study of topical CBD in randomized and controlled studies of elite athletes.

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Potential Role of Cannabidiol on Sports Recovery: A Narrative Review

Cited by 14 publications

References 50 publications

Cannabidiol (CBD) Dosing: Plasma Pharmacokinetics and Effects on Accumulation in Skeletal Muscle, Liver and Adipose Tissue

Cannabidiol (CBD) Dosing: Plasma Pharmacokinetics and Effects on Accumulation in Skeletal Muscle, Liver and Adipose Tissue

Analisis biomotor kecepatan reaksi pada pemain bola voli kelas khusus olahraga Daerah Istimewa Yogyakarta

Topical cannabidiol is well tolerated in individuals with a history of elite physical performance and chronic lower extremity pain

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