Editorial: The safety and efficacy of noninvasive brain stimulation in development and neurodevelopmental disorders

Oberman, Lindsay M.; Enticott, Peter G.

doi:10.3389/fnhum.2015.00544

Cited by 9 publications

(8 citation statements)

References 12 publications

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“…Indeed, in a rat seizure model, Liebetanz et al (2006) reported that seizure threshold was not reduced by anodal tDCS ( Liebetanz et al, 2006 ). tDCS within the standard protocols is considered safe for both adults and children and for both healthy subjects and patients ( Nitsche and Paulus, 2001 , Nitsche and Paulus, 2015 , Nitsche et al, 2003a , Nitsche et al, 2003b , Arul-Anandam et al, 2009 , Borckardt et al, 2011 , Borckardt et al, 2012 , Peruzzotti-Jametti et al, 2013 , Bennabi et al, 2015 , Gillick et al, 2015 , Ho et al, 2015 , Krishnan et al, 2015 , Matsumoto and Ugawa, 2015 , Meron et al, 2015 , Moliadze et al, 2015 , Oberman and Enticott, 2015 , San-Juan et al, 2015 , Smit et al, 2015 , Xu et al, 2015 , Aparício et al, 2016 , Arumugham et al, 2016 , Bikson et al, 2016 , Cha et al, 2016 , Gbadeyan et al, 2016 , Hu et al, 2016 , Muszkat et al, 2016 , Palm et al, 2016 , Rubio et al, 2016 , Shivakumar et al, 2016 , Woods et al, 2016 ). Yet it remains important to be aware of the potential adverse effects of tDCS.…”

Section: Introductionmentioning

confidence: 99%

Adverse events of tDCS and tACS: A review

Matsumoto

Ugawa

2017

Clinical Neurophysiology Practice

221

138

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Section: Introductionmentioning

confidence: 99%

Adverse events of tDCS and tACS: A review

Matsumoto

Ugawa

2017

Clinical Neurophysiology Practice

221

138

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“…In more recent years the availability of non-invasive neuromodulation techniques has raised hope that they might prove an effective tool in the treatment of ASD core manifestations (Oberman and Enticott, 2015 ). Transcranial Magnetic Stimulation (TMS) is a non-invasive neuromodulation technique that has attracted particular interest.…”

Section: Introductionmentioning

confidence: 99%

Repetitive Transcranial Magnetic Stimulation for Treatment of Autism Spectrum Disorder: A Systematic Review and Meta-Analysis

Barahona-Corrêa

Velosa

Chainho

et al. 2018

Front. Integr. Neurosci.

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Background: Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder manifesting as lifelong deficits in social communication and interaction, as well as restricted repetitive behaviors, interests and activities. While there are no specific pharmacological or other physical treatments for autism, in recent years repetitive Transcranial Magnetic Stimulation (rTMS), a technique for non-invasive neuromodulation, has attracted interest due to potential therapeutic value. Here we report the results of a systematic literature review and meta-analysis on the use of rTMS to treat ASD.Methods: We performed a systematic literature search on PubMed, Web of Science, Science Direct, Bielefeld Academic Search, and Educational Resources Information Clearinghouse. Search terms reflected diagnoses and treatment modalities of interest. Studies reporting use of rTMS to treat core ASD or cognitive symptoms in ASD were eligible. Two researchers performed article selection and data extraction independently, according to PRISMA guidelines. Changes in ASD clinical scores or in cognitive performance were the main outcomes. Random effects meta-analysis models were performed.Results: We found 23 eligible reports, comprising 4 case-reports, 7 non-controlled clinical trials, and 12 controlled clinical trials, comparing the effects of real TMS with waiting-list controls (n = 6) or sham-treatment (n = 6). Meta-analyses showed a significant, but moderate, effect on repetitive and stereotyped behaviors, social behavior, and number of errors in executive function tasks, but not other outcomes. Most studies had a moderate to high risk of bias, mostly due to lack of subject- and evaluator-blinding to treatment allocation. Only 5 studies reported stability of these gains for periods of up 6 months, with descriptions that improvements were sustained over time.Conclusions: Existing evidence supports that TMS could be useful to treat some dimensions of ASD. However, such evidence must be regarded with care, as most studies did not adequately control for placebo effects. Moreover, little is known regarding the most effective stimulation parameters, targets, and schedules. There is an urgent need for further randomized, double-blind, sham-controlled trials, with adequate follow-up periods, to test the efficacy of transcranial magnetic stimulation to treat these disorders. Available evidence must be regarded as preliminary and insufficient, at present, to support offering TMS to treat ASD.

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“…Neuromodulation and, more specifically, non-invasive brain stimulation is an intervention aimed at normalizing the putative cortical inhibitory deficit of autism. Among neuromodulation techniques, transcranial magnetic stimulation (TMS) has provided promising results as a possible therapeutic modality in many psychiatric disorders ( Wassermann and Lisanby, 2001 ; Pascual-Leone et al, 2002 ; George et al, 2003 ; Rossi et al, 2009 ; Enticott et al, 2014 ; Rotenberg et al, 2014 ; Oberman and Enticott, 2015 ; Ni et al, 2017 ). Magnetic pulses generated by a current passing through a coil stimulate targeted cortical regions, usually within 2–3 cm of the skull surface ( Rudiak and Marg, 1994 ; George et al, 1999 ; Hoffman and Cavus, 2002 ).…”

Section: Introductionmentioning

confidence: 99%

Exploratory Study of rTMS Neuromodulation Effects on Electrocortical Functional Measures of Performance in an Oddball Test and Behavioral Symptoms in Autism

Sokhadze

Lamina

Casanova

et al. 2018

Front. Syst. Neurosci.

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There is no accepted pathology to autism spectrum disorders (ASD) but research suggests the presence of an altered excitatory/inhibitory (E/I) bias in the cerebral cortex. Repetitive transcranial magnetic stimulation (rTMS) offers a non-invasive means of modulating the E/I cortical bias with little in terms of side effects. In this study, 124 high functioning ASD children (IQ > 80, <18 years of age) were recruited and assigned using randomization to either a waitlist group or one of three different number of weekly rTMS sessions (i.e., 6, 12, and 18). TMS consisted of trains of 1.0 Hz frequency pulses applied over the dorsolateral prefrontal cortex (DLPFC). The experimental task was a visual oddball with illusory Kanizsa figures. Behavioral response variables included reaction time and error rate along with such neurophysiological indices such as stimulus and response-locked event-related potentials (ERP). One hundred and twelve patients completed the assigned number of TMS sessions. Results showed significant changes from baseline to posttest period in the following measures: motor responses accuracy [lower percentage of committed errors, slower latency of commission errors and restored normative post-error reaction time slowing in both early and later-stage ERP indices, enhanced magnitude of error-related negativity (ERN), improved error monitoring and post-error correction functions]. In addition, screening surveys showed significant reductions in aberrant behavior ratings and in both repetitive and stereotypic behaviors. These differences increased with the total number of treatment sessions. Our results suggest that rTMS, particularly after 18 sessions, facilitates cognitive control, attention and target stimuli recognition by improving discrimination between task-relevant and task-irrelevant illusory figures in an oddball test. The noted improvement in executive functions of behavioral performance monitoring further suggests that TMS has the potential to target core features of ASD.

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Editorial: The safety and efficacy of noninvasive brain stimulation in development and neurodevelopmental disorders

Cited by 9 publications

References 12 publications

Adverse events of tDCS and tACS: A review

Adverse events of tDCS and tACS: A review

Repetitive Transcranial Magnetic Stimulation for Treatment of Autism Spectrum Disorder: A Systematic Review and Meta-Analysis

Exploratory Study of rTMS Neuromodulation Effects on Electrocortical Functional Measures of Performance in an Oddball Test and Behavioral Symptoms in Autism

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