COVID-19-associated coagulopathy and acute kidney injury in critically ill patients

Silva, Bruno Caldin da; Cordioli, Ricardo Luiz; Santos, Bento Fortunato Cardoso dos; Guerra, João Carlos de Campos; Rodrigues, Roseny dos Reis; Souza, Guilherme Martins de; Ashihara, Carolina; Midega, Thais Dias; Campos, Niklas Söderberg; Carneiro, Bárbara Vieira; Campos, Flávia Nunes Dias; Guimarães, Hélio Penna; Matos, Gustavo Faissol Janot de; Aranda, Valdir Fernandes de; Ferraz, Leonardo José Rolim; Corrêa, Thiago Domingos

doi:10.31744/einstein_journal/2023ao0119

Einstein (São Paulo)

2023

DOI: 10.31744/einstein_journal/2023ao0119

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COVID-19-associated coagulopathy and acute kidney injury in critically ill patients

Bruno Caldin da Silva,

Ricardo Luiz Cordioli,

Bento Fortunato Cardoso dos Santos

et al.

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COVID-19 and Kidney: The Importance of Follow-Up and Long-Term Screening

Rai

2023

Life

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Renal involvement and kidney injury are common in COVID-19 patients, and the symptoms are more severe if the patient already has renal impairment. Renal involvement in COVID-19 is multifactorial, and the renal tubule is mainly affected, along with podocyte injury during SARS-CoV-2 infection. Inflammation, complement activation, hypercoagulation, and crosstalk between the kidney and lungs, brain, and heart are contributory factors. Kidney injury during the acute phase, termed acute kidney injury (AKI), may proceed to chronic kidney disease if the patient is discharged with renal impairment. Both AKI and chronic kidney disease (CKD) increase mortality in COVID-19 patients. Further, COVID-19 infection in patients suffering from CKD is more severe and increases the mortality rate. Thus, it is important to address both categories of patients, either developing AKI or CKD after COVID-19 or previously having CKD, with proper management and treatment. This review discusses the pathophysiology involved in AKI and CKD in COVID-19 infection, followed by management and treatment of AKI and CKD. This is followed by a discussion of the importance of screening and treatment of CKD patients infected with COVID-19 and future perspectives to improve treatment in such patients.

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COVID-19 and Kidney: The Importance of Follow-Up and Long-Term Screening

Rai

2023

Life

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COVID-19-associated coagulopathy and acute kidney injury in critically ill patients

Cited by 1 publication

References 53 publications

COVID-19 and Kidney: The Importance of Follow-Up and Long-Term Screening

COVID-19 and Kidney: The Importance of Follow-Up and Long-Term Screening

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