Relation between red blood cell distribution width and acute kidney injury in patients with sepsis

Abstract

Objective:The objective of the present study is to evaluate the association of red blood cell distribution width with acute kidney injury in sepsis. Methods: This is a retrospective study of 849 critically ill patients with sepsis in intensive care unit. Demographic data, renal function, inflammation, complete blood count, and acid-base parameters were compared between acute kidney injury and non-acute kidney injury groups. Therefore, a multivariate analysis was performed to observe independent predictive factors. Results: Comparatively, higher levels of C-reactive protein, lactate, red blood cell distribution width, and Simplified Acute Physiology Score 3 were found in the acute kidney injury group. The study showed a higher frequency of women, hemoglobin (Hgb) concentration, platelets, bicarbonate and PaO 2 /FiO 2 ratio in the nonacute kidney injury group. In addition, there was an independent association of comorbiditychronic kidney disease [OR 3.549, 95%CI: 1.627-7.743; p<0.001], urea [OR 1.047, 95%CI: 1.036-1.058; p<0.001] and RDW [OR 1.158, p=0.005] with acute kidney injury in sepsis patients. Conclusion: As an elective risk factor, red blood cell distribution width was independently associated with sepsis-related acute kidney injury. Thus, red blood cell distribution width acts like a predictive factor for sepsis-induced acute kidney injury in intensive care unit admission.

Red blood cell distribution width improves the prediction of 28-day mortality for patients with sepsis-induced acute kidney injury: A retrospective analysis from MIMIC-IV database using propensity score matching

“…Nevertheless, some previous studies have investigated the role of RDW in the diagnosis and risk assessment of diseases. [ [25] , [26] , [27] ] High RDW values may indicate changes in the lifespan of RBCs, which typically occur due to the lack of serum EPO and the impairment of renal function. [ 8 , 9 , 28 ] Conversely, renal function plays a critical role in iron balance in organisms, which is also reflected in the variation of the RDW.…”

“…Ramires et al. [ 26 ] reported that the RDW was an independent risk factor for AKI in patients with sepsis. SI-AKI and sepsis differ in terms of characteristics and prognoses because the kidney is a target organ with metabolic functions.…”