Study of muscle fibers of the extensor digitorium longus and soleus muscles of C57BL/6 females exposed to glyphosate during pregnancy and lactation

Barbosa, Ariadne; Oliveira, Mylena Campos de; Kuhn-Fraga, Camila; Ribeiro, Lucinéia de Fátima Chasko; Balbo, Sandra Lucinei; Torrejais, Márcia Miranda

doi:10.31744/einstein_journal/2021ao5657

Einstein (São Paulo)

2021

DOI: 10.31744/einstein_journal/2021ao5657

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Study of muscle fibers of the extensor digitorium longus and soleus muscles of C57BL/6 females exposed to glyphosate during pregnancy and lactation

Ariadne Barbosa¹,

Mylena Campos de Oliveira²,

Camila Kuhn-Fraga³

et al.

Abstract: Study of muscle fibers of the extensor digitorium longus and soleus muscles of C57BL/6 females exposed to glyphosate during pregnancy and lactation Estudo das fibras musculares dos músculos extensor longo dos dedos e sóleo de fêmeas C57BL/6 expostas ao glifosato durante a prenhez e a lactação

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Cited by 2 publications

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Maternal exposure to glyphosate‐based herbicide promotes changes in the muscle structure of C57BL/6 mice offspring

Barbosa

Zazula

Oliveira

et al. 2022

The Anatomical Record

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Glyphosate (GBH) is a worldwide consumption pesticide and is used in the formulation of Roundup®, one of the most commercialized herbicides in the world. Maternal exposure to this herbicide can promote changes and adaptations in the offspring; however, the effects on skeletal muscle are poorly understood. In this sense, the present study sought to evaluate the effect of exposure to GBH on the characteristics of the soleus (SOL) and extensor digitorum longus (EDL) muscles. C57BL/6 pregnant female mice were divided into two groups: control (CTL) receiving water and glyphosate (GBH; n = 6) receiving 0.5% glyphosate. Male puppies were designated according to the group to which the mothers belonged, such as CTL‐F1 and GBH‐F1 and then euthanized at 150 days of age. There was a reduction in body weight and nasoanal length of animals exposed to GBH, while there was an increase in EDL weight, reduction in the proportion of fibers and number of nuclei, and an increase in the connective tissue of the SOL. The animals exposed to GBH presented higher values of body characteristics, mainly adiposity gain, while they presented a reduction in neuromuscular junctions (NMJ), and an increase in fibrosis in the SOL muscle, while there was a reduction in the number of nuclei, and an increase in the weight of the EDL muscle. These findings indicate that glyphosate can promote changes in the offspring's body growth, the deposition of adipose panicles and its effects on muscle can lead to changes in the structure and functioning of this tissue.

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Maternal exposure to glyphosate‐based herbicide promotes changes in the muscle structure of C57BL/6 mice offspring

Barbosa

Zazula

Oliveira

et al. 2022

The Anatomical Record

Self Cite

View full text Add to dashboard Cite

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Association between urinary glyphosate levels and hand grip strength in a representative sample of US adults: NHANES 2013–2014

Fang,

Wang,

Lin

2024

Front. Public Health

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IntroductionGlyphosate, a widely utilized herbicide globally, has been linked to various health issues, including cancer, birth abnormalities, and reproductive issues. Additionally, there is growing experimental support indicating potential harm to skeletal muscles. Despite this, the impact of glyphosate on human muscle health remains unclear.MethodsWe examined information gathered from the 2013-2014 National Health and Nutrition Examination Survey (NHANES), which included 1466 adults aged 18 or older. Our primary aim was to investigate the relationship between glyphosate exposure and hand grip strength, as well as its influence on lean muscle mass.Results and discussionOur investigation uncovered a detrimental correlation between glyphosate exposure and all measures of grip strength, except for the second test of the first hand. Specifically, we observed a statistically significant adverse association between glyphosate exposure and combined grip strength, which is calculated as the sum of the highest readings from both hands (ß coefficient of −2.000, S.E. = 0.891, p = 0.040). We did not observe a significant correlation between glyphosate levels, lean muscle mass, and the likelihood of reaching maximum grip strength meeting sarcopenia criteria. Additionally, we observed an interaction between age and glyphosate, as well as between body mass index (BMI) and glyphosate, concerning the association with combined grip strength. In this comprehensive analysis of NHANES data, our study reveals a potential association between glyphosate exposure and hand grip strength in the adult population. Our findings suggest the need for deeper exploration into the health effects of glyphosate exposure and its impact on muscle strength, shedding light on possible public health concerns.

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Study of muscle fibers of the extensor digitorium longus and soleus muscles of C57BL/6 females exposed to glyphosate during pregnancy and lactation

Cited by 2 publications

References 20 publications

Maternal exposure to glyphosate‐based herbicide promotes changes in the muscle structure of C57BL/6 mice offspring

Maternal exposure to glyphosate‐based herbicide promotes changes in the muscle structure of C57BL/6 mice offspring

Association between urinary glyphosate levels and hand grip strength in a representative sample of US adults: NHANES 2013–2014

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