Medication regimen complexity of coronary artery disease patients

Tinoco, Marlon Silva; Groia-Veloso, Ronara C.; Santos, Jéssica Nathália Domingos dos; Cruzeiro, Maria Gabriela Martins; Dias, Bianca Menezes; Reis, Adriano Max Moreira

doi:10.31744/einstein_journal/2021ao5565

Cited by 3 publications

(1 citation statement)

References 27 publications

(28 reference statements)

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“…The main objective is to prevent and to solve pharmacotherapy problems, achieving good clinical outcomes, reducing risks, and contributing to improved efficiency and quality of health care. 18 The characterization of the medication regimen complexity index has been performed for different groups of patients, including subjects with diabetes, 19 psychiatric disorders, 20 coronary diseases, 21 HIV infection 22 and elderly. 23 However, studies involving transplant patients are scarce, 24 especially in Brazil.…”

Section: Introductionmentioning

confidence: 99%

Medication Regimen Complexity Index After Kidney Transplant in Fortaleza, Brazil

et al. 2023

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Background: The Medication Regimen Complexity Index (MRCI) is a reliable tool to evaluate the complexity of pharmacotherapy and can predict the treatment adherence of post-transplant patients. The MRCI was evaluated in the post-kidney transplant period. Materials and Methods: In a descriptive, observational, and cross-sectional study, we evaluated the pharmacotherapy and the MRCI of kidney transplant patients for a year in a kidney transplant outpatient clinic at a university hospital in Fortaleza, Brazil. A convenience sample was obtained and analyzed the records of kidney transplant recipients who had at least two visits with pharmacists. The main outcome measures are characterization of immunosuppressive regimen, MRCI score, correlations between MRCI score and a period post-transplant. Results: 109 patients were included in the study. The predominant class was antineoplastic and immunomodulating agents (27.7%), and the most frequent immunosuppressive regimen was tacrolimus, mycophenolate sodium and prednisone (63.30%). The mean points in MRCI were 46; minimum of 19 points associated with 3 drugs and maximum of 83.5 points with 16. About sections A, B and C of the MRCI, the means found were 2.60, 13.2 and 30.6 points, respectively. Correlations between MRCI score and number of medications were checked, and a period less than 180 days after transplantation had score >40 points. Conclusion: MRCI in the kidney transplant patient is linked to the number of medications, dose and additional instructions. To improve adherence to the treatment, patient orientation is necessary especially in the first year after transplant.

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Section: Introductionmentioning

confidence: 99%

Medication Regimen Complexity Index After Kidney Transplant in Fortaleza, Brazil

et al. 2023

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Illness Perception, Self-Efficacy, and Medication Adherence in Patients With Coronary Artery Disease: A Path Analysis of Conceptual Model

et al. 2023

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Introduction Illness perception and self-efficacy in patients with coronary artery disease (CAD) may affect medication adherence, which is one of the most important challenges in disease management in this group of patients. Objective The present study aimed to investigate the factors influencing medication adherence in CAD patients, especially the effect of illness perception and self-efficacy. Methods This study was cross-sectional and conducted from April to September 2021. A total of 259 patients with confirmed CAD were selected by convenience sampling method based on inclusion criteria. Illness perception, self-efficacy, and medication adherence were investigated using Brief IPQ, SCSES, and MARS_10 questionnaires, respectively. The data were analyzed using the STATA software (version 14) and the regression path analysis method. Results Patients had moderate illness perception and high self-efficacy, and 61.8 of them adhered to their medication regimen. Greater illness perception, better self-efficacy, and higher education had a positive effect on medication adherence, and increasing age had a negative effect on it. The final path model shows a good fit of the data in the model (χ2: 0.37, df: 274, χ2/df: 0.36, CFI: 1, IFI: 0.95, TLI: 1.07, and RMSEA: 0.00). Conclusion The results of the present study suggest that patients’ illness perception can play an important role in predicting self-efficacy in disease management and the level of medication adherence in patients with CAD. To improve self-efficacy and medication adherence, future intervention studies should focus on the patient's illness perceptions and their improvement.

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Levels of adherence to treatment, illness perception and acceptance of illness in patients with coronary artery disease - descriptive and correlational study

Dugunchi,

Mudgal,

Marznaki

et al. 2024

BMC Cardiovasc Disord

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Background Understanding the disease and its acceptance significantly influence adherence to prescribed medications, a critical aspect in managing coronary artery disease (CAD). This study is designed to explore the multifaceted factors influencing medication adherence specifically in CAD patients. Of particular interest is investigating the interconnectedness between medication adherence, the perception of illness, and the level of acceptance of the illness itself among these individuals. Methods This cross-sectional study involved 280 confirmed CAD patients who were selected through a convenience sampling method adhering to predefined inclusion criteria. The study was conducted between March and September 2023. Three primary parameters—medication adherence, illness perception, and acceptance of illness—were evaluated using standardized tools: The Morisky Medication Adherence Scale-8, Illness Perception Questionnaire-Brief, and Acceptance of Illness Scale. Statistical analyses using SPSS (version 25) were used to analyze the data. Results Patients had moderate illness perception (51.82 ± 7.58) and low acceptance to illness (16.98 ± 4.75), and 61.8 of them adhered to their medication regimen. A positive relationship between acceptance of illness and medication adherence (r = 0.435, p-value < 0.01) was found. Level of education, type of drug and marital status had significantly impact on medication adherence, and gender, level of education, intention to stop drug and marital status were associated with acceptance of illness (p < 0.05). Conclusion These results underscore the pivotal role of medication adherence in CAD management. Future interventions should target improving illness perception and acceptance of illness among CAD patients to enhance their overall adherence to prescribed medications and ultimately improve disease management.

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Medication regimen complexity of coronary artery disease patients

Cited by 3 publications

References 27 publications

Medication Regimen Complexity Index After Kidney Transplant in Fortaleza, Brazil

Medication Regimen Complexity Index After Kidney Transplant in Fortaleza, Brazil

Illness Perception, Self-Efficacy, and Medication Adherence in Patients With Coronary Artery Disease: A Path Analysis of Conceptual Model

Levels of adherence to treatment, illness perception and acceptance of illness in patients with coronary artery disease - descriptive and correlational study

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