Endotracheal tubes (ETT) passed inside the human trachea witness tube bending at different angles, affecting the ocal fluid flow dynamics. This induces a variable mechanical ventilation performance across patients’ comfortability evels. Our understanding of the ocal fluid flow dynamics phenomena is thus crucial to enhance the maneuverability of ETT under operation. For the first time to our knowledge, we shed ight on ETT through computational fluid dynamics (CFD) to investigate the bending effect of ETT on the ocal airflow in volume-controlled mechanical ventilation. We considered an ETT with 180° arc bend configuration, including Murphy’s eye. We identified several flow phenomena associated with the bending, such as flow asymmetries, secondary flows, and vortex dynamics throughout the tube.