Muscular resistance, hypertrophy and strength training equally reduce adiposity, inflammation and insulin resistance in mice with diet-induced obesity

Abstract

Objective To evaluate the effect of three types of muscular resistance training on adiposity, inflammation levels and insulin activity in Swiss mice with fat-rich diet-induced obesity.Methods Lean and obese male Swiss mice were selected and allocated to one of eight groups comprising eight mice each, as follows: standard diet + no training; standard diet + muscular resistance training; standard diet + hypertrophy training; standard diet + strength training; high-fat diet + no training; high-fat diet + muscular resistance training; high-fat diet + hypertrophy training; high-fat diet + strength training. The training protocol consisted of stair climbing for a 10-week period. Blood samples were collected for lactate analysis, glucose level measurement and insulin tolerance test. After euthanasia, adipose tissues were removed and weighed for adiposity index determination. Fragments of epididymal adipose tissue were then embedded for histological analysis or homogenized for tumor necrosis factor alpha level determination using the ELISA method.Results Ausency of differences in total training volume and blood lactate levels overall emphasize the similarity between the different resistance training protocols. Body weight loss, reduced adipocyte area and lower adiposity index were observed in trained obese mice, regardless of training modality. Different training protocols also improved insulin sensitivity and reduced inflammation levels.Conclusion Resistance training protocols were equally effective in reducing body fat, inflammation levels and insulin resistance in obese mice.

Trends in insulin resistance: insights into mechanisms and therapeutic strategy

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Healthy versus Unhealthy Adipose Tissue Expansion: the Role of Exercise

“… 10 It is important to note that the effects of leptin and adiponectin on endothelial cells are largely opposite, with leptin promoting and adiponectin inhibiting angiogenesis. 48 Interestingly, most exercise studies report improved insulin sensitivity, 49 , 50 increased angiogenesis, 41 and reduced leptin 51 and inflammation in adipose tissue, 51 - 53 with no change or a slight increase in adiponectin 54 - 56 reported in obese animals. Similar increases in angiogenesis and decreases in leptin and inflammation have been observed, with no change in adiponectin, in humans following 12 weeks of aerobic exercise.…”

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