Kaposi sarcoma of th e penis in anHIV-negative patient

Abstract

Kaposi sarcoma is an angioproliferative disorder that ranges from a single indolent skin lesion to respiratory and gastrointestinal/visceral involvement. Kaposi sarcoma is rare in non-immunosuppressed patients. Nineteen cases of penile Kaposi sarcoma in HIV-negative patients were reported in 2012. We present the case report of a 48-year-old male patient with no previous medical history, who came to our urology clinic presenting a purple-color papule on the penis glans. Lab tests revealed negative serology for HIV, but tissue PCR was positive for human herpesvirus 8. Histopathology examination after lesion excision was compatible with Kaposi sarcoma. No other cutaneous or mucosal lesions were present. Primary Kaposi sarcoma of the penis is rare, but may occur in non-immunosuppressed patients.

Primary penile Kaposi’s sarcoma in HIV-seronegative patient: a case report and literature review

“…As concerned to the immunological status, three patients with isolated penile KS reported an immunosuppression HIV related ( 23 , 24 ). The lesions described are definitely variable for manifestation, (nodule ( 23 , 25 – 39 ), papular ( 22 , 34 , 40 – 44 ), ulcerated ( 27 , 39 , 45 ), granulomatous ( 21 ), verrucous ( 46 ) dimension 0-5mm ( 24 , 31 – 33 , 35 , 40, 42, 43, 47), >6mm ( 21 , 26 , 28 , 30 , 34 , 36 , 37 , 40 – 42 , 46 ), site (gland ( 21 – 23 , 25 , 26 , 28 – 45 , 48 ), coronal sulcus ( 22 , 26 , 29 , 37 , 40 , 44 , 45 ), prepuce ( 24 , 47 , 49 ), penilshaft ( 27 , 46 , 48 ), scrotum ( 23 ), frenulum ( 30 )), color (reddish ( 23 , 25 – 27 , 29 , 32 , 34 , 36 , 40 , 44 , 45 , 49 ), purplish ( 23 , 29 , 30 , 33 , 39...…”

“…Other approaches described in literature could include radiotherapy ( 25 , 29 , 37 , 42 ), subtotal circumcision associated with biopsy ( 45 ), cryotherapy associated with 5% Imiquimod cream ( 21 ), excisional biopsy associated with IFNα ( 32 ), biopsy with chemotherapy ( 39 ), CO2 ( 48 ), biopsy with radiotherapy ( 46 ). Furthermore, in five cases no therapy was performed ( 22 , 23 , 33 , 34 ), two of them for the spontaneous regression of the disease ( 33 , 34 ). The clinical course of primary penile KS is variable and no standardized follow-up exists to date.…”

“…In general, local recurrences are rare if the primary tumor is completely removed. In one of them ( 33 ) the authors refer recurrence of a new penis lesion after seven months, then after one year two lesions on both legs and one on conjunctiva. Other cases of recurrences occurred for therapy with biopsy with IFNα ( 32 ) and with CO2 ( 48 ).…”

Kaposi's sarcoma of the penis in HIV-negative patients: case series

“…Саркома Капоши полового члена встречается очень редко -3-5 % всех злокачественных опухолей этой локализации [12][13][14][15][16].…”

“…По данным J. F.A. Guevara и соавт., в 2012 г. было зарегистрировано 19 случаев саркомы Капоши полового члена у ВИЧ-отрицательных пациентов [13].…”