Metabolic syndrome: definition and prevalence in children

Chen, Wei; Berenson, Gerald S.

doi:10.2223/jped.1584

Cited by 37 publications

(29 citation statements)

References 14 publications

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“…Paralelamente, crescem as evidências científicas de que os distúrbios metabólicos que habitualmente acompanham o excesso de gordura corpórea já se manifestam na infância [2][3][4][5] . A síndrome metabólica, descrita como um grupo de distúrbios que inclui obesidade, resistên-cia à insulina, dislipidemia, hipertensão arterial e outras anomalias metabólicas associadas com doença cardiovascular 6,7 , possivelmente está presente em crianças já na fase pré-escolar 4,5 . A maior dificuldade no presente, tanto para estudos científicos como para a clínica, é encontrar os adequados pontos que corte para a avaliação de indicadores como lipemia, pressão arterial, circunferência abdominal, resistência periférica à insulina (RPI), glicemia e insulinemia 5 .…”

Section: Introductionunclassified

Determination of glycemia and insulinemia and the homeostasis model assessment (HOMA) in schoolchildren and adolescents with normal body mass index

et al. 2008

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ResumoObjetivo: Determinar, entre um grupo de crianças e adolescentes eutróficos, os valores de glicemia e insulinemia de jejum e de índice homeostasis model assessment (HOMA). Métodos: Estudo de corte transversal realizado em duas escolas públicas de Ribeirão Preto (SP). Foram obtidas medidasantropométricas, dados pessoais e colhida amostra de sangue venoso de 447 crianças e adolescentes eutróficos, de ambos os sexos, com idades entre 7 e 17,9 anos, maturadores médios. Mediram-se glicemia de jejum e insulinemia de jejum e calculou-se o HOMA. Utilizando o teste de Mann-Whitney, foram realizadas comparações entre os valores obtidos para meninos e meninas em cada faixa etária. Posteriormente, utilizando o teste de Kruskal-Wallis, foram comparados os valores em cada faixa etária para meninos e meninas.Resultados: Entre as meninas, os valores de glicemia apresentaram variação entre 7 a 8,9 anos (p = 0,0005). Para ambos os sexos, em relação à insulinemia, ocorreu variação de acordo com a idade (p < 0,001), com valores mais elevados na faixa de 13 a 14,9 anos. Os valores de HOMA apresentaram variação significativa de acordo com a idade (p < 0,001) para meninos e meninas, com valores crescentes até a faixa de 13 a 14,9 anos. Conclusões:Os dados apontam para a necessidade do estabelecimento de curvas de referência para os três indicadores.J Pediatr (Rio J). 2008;84(2):136-140: Obesidade, hiperinsulinismo, insulina, hiperglicemia, síndrome X metabólica. AbstractObjective: To determine fasting glycemia and insulinemia levels and the HOMA index in a group of children and adolescents with normal body mass index (BMI).Methods: This was a cross-sectional study conducted at two public schools in Ribeirão Preto, SP, Brazil. A total of 447 children and adolescents of both sexes, with normal BMI, aged 7 to 17.9 years and of average maturity for their age, underwent anthropometric measurements and provided personal data and a sample of venous blood so that glycemia, insulinemia and HOMA index could be determined. The results obtained for boys and girls were compared for each age range using the Mann-Whitney test. The results within each age band were then compared for boys and girls using the Kruskal-Wallis test. Results:Glycemia results varied from 7 to 8.9 years (p = 0.0005). Fasting insulinemia varied significantly with age in both sexes (p < 0.001), with the highest values observed among children aged 13 to 14.9 years. HOMA indices varied significantly with age in both boys and girls (p < 0.001), with values that increased progressively up to the age band of 13 and 14.9 years.Conclusions: These data demonstrate the necessity of establishing reference curves for these three indicators. J Pediatr (Rio J)

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Section: Introductionunclassified

Determination of glycemia and insulinemia and the homeostasis model assessment (HOMA) in schoolchildren and adolescents with normal body mass index

et al. 2008

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“…1 In parallel, scientific evidence is mounting up that suggests that the metabolic disorders that habitually accompany excess body fat are already manifest during childhood. [2][3][4][5] The metabolic syndrome is defined as a group of disorders that includes obesity, insulin resistance, dyslipidemia, arterial hypertension and other metabolic anomalies associated with cardiovascular disease, 6,7 and it is possible that this syndrome is already affecting children even before they start school. 4,5 Currently, the greatest difficulty facing both scientific studies and clinicians is the identification of adequate cutoff points for assessing indicators such lipemia, arterial blood pressure, waist circumference, peripheral insulin resistance (PIR), glycemia and insulinemia.…”

Section: Introductionmentioning

confidence: 99%

Determinação dos valores de glicemia, insulinemia e índice (HOMA) em escolares e adolescentes eutróficos

Nogueira‐de‐Almeida

Pinho

Ricco

et al. 2008

J. Pediatr. (Rio J.)

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Objective: To determine fasting glycemia and insulinemia levels and the HOMA index in a group of children and adolescents with normal body mass index (BMI).Methods: This was a cross-sectional study conducted at two public schools in Ribeirão Preto, SP, Brazil. A total of 447 children and adolescents of both sexes, with normal BMI, aged 7 to 17.9 years and of average maturity for their age, underwent anthropometric measurements and provided personal data and a sample of venous blood so that glycemia, insulinemia and HOMA index could be determined. The results obtained for boys and girls were compared for each age range using the Mann-Whitney test. The results within each age band were then compared for boys and girls using the Kruskal-Wallis test.Results: Glycemia results varied from 7 to 8.9 years (p = 0.0005). Fasting insulinemia varied significantly with age in both sexes (p < 0.001), with the highest values observed among children aged 13 to 14.9 years. HOMA indices varied significantly with age in both boys and girls (p < 0.001), with values that increased progressively up to the age band of 13 and 14.9 years.Conclusions: These data demonstrate the necessity of establishing reference curves for these three indicators.J Pediatr (Rio J). 2008;84(2):136-140: Obesity, hyperinsulinism, insulin, metabolic syndrome X.

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“…[25][26][27] Prevalence of MS in American adolescents was identified in 6.8% of the overweight adolescents and in 28.7% of the obese adolescents. 28 A Brazilian study with obese children demonstrated the prevalence of MS to be 17.3% of the obese children aged between 7 and 10 years.…”

Section: Secondary Dyslipidemiamentioning

confidence: 99%

Prevenção da aterosclerose e tratamento medicamentoso de anormalidades lipídicas de alto risco em crianças e adolescentes

Castro¹,

Oliveira²

2009

J. Pediatr. (Rio J.)

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Objective: To discuss risk factors of atherosclerosis in pediatrics, dietary and physical activity guidelines, and, mainly, drug treatment of high-risk lipid abnormalities.Sources: Data were obtained from articles indexed in MEDLINE, published over the last 5 years. Summary of the findings:Children with severe dyslipidemia or additional risk factors such as family history of early cardiovascular disease or other signs of metabolic syndrome may need treatment with hypolipidemic drugs. New recommendations from the U.S. guidelines indicate drug treatment before the age of 10 years according to the magnitude of the additional risk factors for cardiovascular disease. Pediatricians should know when to diagnose dyslipidemia, when to indicate drug treatment and which medication can be used in children and adolescents with the least risk or harm to their development. Conclusions:The first-line treatment of dyslipidemia consists of lifestyle changes, focusing on prevention. Children with high-risk lipid abnormalities should be considered for drug treatment. Decisions to be made together with the parents must be evaluated taking into consideration risks and benefits of the medication to the patient.

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Metabolic syndrome: definition and prevalence in children

Abstract: A síndrome metabólica, um grupo de distúrbios que inclui obesidade, resistência à insulina, dislipidemia e hiperten-

Cited by 37 publications

References 14 publications

Determination of glycemia and insulinemia and the homeostasis model assessment (HOMA) in schoolchildren and adolescents with normal body mass index

Determination of glycemia and insulinemia and the homeostasis model assessment (HOMA) in schoolchildren and adolescents with normal body mass index

Determinação dos valores de glicemia, insulinemia e índice (HOMA) em escolares e adolescentes eutróficos

Prevenção da aterosclerose e tratamento medicamentoso de anormalidades lipídicas de alto risco em crianças e adolescentes

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