Sensitization to inhalant and food allergens in Brazilian atopic children by <i>in vitro</i> total and specific IgE assay. Allergy Project - PROAL

Abstract

Fonte financiadora: Pharmacia do Brasil (doou kits para dosagens).Artigo submetido em 015.12.03, aceito em 03.03.04. AbstractObjective: To determine the frequency of sensitization to inhalant and food allergens in children seen at Brazilian allergy services.Patients and methods: Total and specific IgE serum levels to inhalant and food allergens (RAST, UniCAP ® Pharmacia) were measured in 457 children accompanied in pediatric allergy services and in 62 control children age matched. RAST equal or higher than class 1 was considered as positive (R+).Results: Frequency of R+ was significantly higher among atopics (361/457, 79%) when compared to controls (16/62, 25.8%). There were no differences according to gender. The frequency of R+ to all allergens evaluated were higher among atopics when compared to controls. Significantly higher total IgE serum levels were observed among the atopics with R+ in comparison to those with R-. The frequency of R+ to main inhalant allergens were: D. pteronyssinus = 66.7% x 14.5% (p < 0.05), D. farinae = 64.5% x 17.8% (p < 0.05), B. tropicalis = 55.2% x 19.4% (p < 0.05), cockroach = 32.8% x 9.7% (p < 0.05), and cat = 12% x 8.1%. In relation to food allergens we observed: fish = 29.5% x 11.3% (p < 0.05), egg = 24.4% x 4.8% (p < 0.05), cow s milk = 23.1% x 3.2% (p < 0.05), wheat = 20% x 8.1% (p < 0.05), peanuts = 14% x 4.8% (p < 0.05), soy = 11.8% x 4.8% (p < 0.05), and corn = 10.6% x 4.8% (p < 0.05). With respect of age, food allergen sensitization predominates in young children whereas the inverse occurs with inhalant allergens.Conclusions: There was a predominant frequency of sensitization to inhalant allergens, mainly house dust mites in the evaluated patients. Food allergens were also responsible for a significant proportion of sensitization, mainly in infants. ResumoObjetivo: Determinar a freqüência de sensibilização a alérgenos inalantes e alimentares em crianças atendidas em serviços brasileiros de alergia. Pacientes e métodos: IgE sérica total e específica (RAST) a alérgenos inalantes e alimentares (UniCAP ® Pharmacia) foram determinados em 457 crianças acompanhadas em serviços de alergia pediátrica e em um grupo de controles (n = 62). Resultados classe igual ou maior que 1 foram considerados positivos (R+).Resultados: A freqüência de R+ foi significantemente maior entre os atópicos (361/457, 79%) quando comparados aos controles (16/62, 25,8%). Não houve diferenças quanto ao sexo. A prevalência de R+ entre os atópicos foi significantemente maior para todos os alérgenos avaliados. Os níveis séricos de IgE total foram significantemente mais elevados entre os atópicos com R+ quando comparados aos com R-. Comparando-se atópicos e controles, a freqüência de R+ para os principais alérgenos inalantes foi como segue: D. pteronyssinus = 66,7 versus 14,5% (p < 0,05), D. farinae = 64,5 versus 17,8% (p < 0,05), B. tropicalis = 55,2 versus 19,4% (p < 0,05), barata = 32,8 versus 9,7% (p < 0,05) e gato = 12 versus 8,1%. Com os alimentos, observouse: peixe = 29,5 versus 11,3% (p < 0,05), ovo =...

Increased sensitization to several allergens over a 12‐year period in Brazilian children

“…1,3 The first Brazilian Allergy Project (PROAL I) study was carried out in 2004 with the objective of documenting the sensitization rates to the major allergens in Brazilian allergic children. 4 This was the first study of its kind, which contributed to better understanding of regional differences and enabled comparison with other countries. During the past decade, the prevalence of asthma and allergic diseases in children and adolescents has increased.…”

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The Prevalence and Patterns of Allergic Sensitization in Isparta, Turkey

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Brazil nut allergy: A review

“…In Brazil, Guimarães et al (2015) collected information from parents of pre-school children with allergy to different foods and found the following: milk (42.7%), pork (11.6%), fruits (10.9%), chocolate (9.4%), and eggs (9.2%). Investigating the prevalence of sensitivity to food allergens in children in Brazil, Naspitz et al (2004) reported reaction to food allergens in subjects tested for IgE sensitivity, indicating a significantly greater proportion of sensitive individuals than non-sensitive ones. Table 3 shows the prevalence of tree nuts allergy in patients from several countries.…”