One-Pot Synthesis of Benzopinacolone Derivatives from Acetophenones
Andréia Joice O. Meira,
Thiago B. de Queiroz,
Alvaro T. Omori
Abstract:Pinacolone and benzopinacolone derivatives are an important class of organic compounds due to their uses in polymer synthesis and more recently as biologically active compounds. The conventional synthesis of such molecules is generally done in two steps, the pinacol coupling followed by the pinacol/pinacolone rearrangement. Aiming to prepare benzopinacolone derivatives in a greener fashion, we present here a one-step synthesis from acetophenones in the presence of zinc and tert-butyl chloride. To develop the m… Show more
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