Computer-Aided Drug Design Studies in Association with in vitro Antileishmanial Tests for New Chalcones
Gleice da Silva,
Francisnaira Santos,
Fernando Leite
et al.
Abstract:In silico and in vitro tests can reveal promising anti-leishmania activity for natural products and their derivatives. The aim of this study was to investigate in silico the pharmacological activities of potential new chalcones and their leishmanicidal potential in vitro. The in silico study was carried out using the PASS, MolPredictX and Molegro Virtual Docker 6.0 programs. Antiparasitic activity was assessed in axenic promastigote and amastigote forms of Leishmania braziliensis. The cytotoxicity tests used t… Show more
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