New Compounds Isolated from Trichilia pseudostipularis (Meliaceae)

Abstract

The genus Trichilia, belonging to the Meliaceae family, comprises ca. 102 species, some of which have been the subject of phytochemical studies. Compounds of different classes with cytotoxic, antimicrobial, and antioxidant activities were isolated from Thichilia. Trichilia pseudostipularis, a native species, is distributed along the entire Brazilian coast, from southern Santa Catarina to Bahia. Due to the inexistence of previous chemical studies, their wood and roots were investigated. Compounds 3,4-dihydro-4-isopropyl-6-methylnaphthalen-1(2H)-one (1), 3,4-dihydro-7-hydroxy4-isopropyl-6-methylnaphthalen-1(2H)-one (2), and pseudostipulariol (3) were isolated from wood, while the lactone derivate rel-(2S,3S,4R)-3-hydroxy-4-methyl-2-(13”-phenyl-1’-n-tridecyl)- butanolide (4) was isolated from the roots. Compounds 3 and 4 are reported for the first time.