Putative Inhibitor of TcCYP51 from a Library of Approved Drugs: A Virtual Screening Study
Luiz Augusto Flores-Junior,
Eldio dos Santos,
Estela Maris Muri
et al.
Abstract:Chagas disease is a public health problem, particularly in Latin America. The available treatment consists of two poorly effective drugs in the chronic phase of this parasitic disease. Considering the lack of effective treatment, alternatives are sought, such as the search focused on the biological targets of the etiologic agent. Based on this strategy, the role of Trypanosoma cruzi sterol 14α-demethylase (TcCYP51) in ergosterol seems promising. In this work, we apply the virtual screening approach to a propos… Show more
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