Eudragit® L100 Post-Modification via Ugi Multicomponent Reaction

Abstract

This work investigated the post-modification of commercial poly(methyl mechacrylate-coacrylic acid) using the versatile multicomponent Ugi reaction. This reaction introduces diverse functionalities to tailor the polymer properties effectively. The commercial copolymer which is known for biocompatibility and drug delivery application was subjected to the Ugi reaction, altering its chemical structure. The structure of the modified polymer was checked by Fourier transform infrared spectroscopic and nuclear magnetic resonance and thermal characterizations, confirming successful Ugi component integration. Additionally, gel permeation chromatography assessed molecular weight changes. Results revealed enhanced thermal stability of the modified polymers compared to unmodified polymer, potentially advantageous in high-temperature applications. In summary, the study demonstrates efficient poly(methyl mechacrylate-co-acrylic acid) post-modification through a multicomponent Ugi reaction, yielding tailored polymers. Comprehensive spectroscopic, thermal, and gel permeation analyses shed light on structural changes and improved stability, pivotal for innovative applications like drug delivery.