Ionic Liquid-Catalyzed Multicomponent Synthesis of Isoxazole-5(4H)-ones: in vitro Activities and Principal Component Analysis
Yasmine Queiroz,
Yasmin de Freitas,
Juliana Lima
et al.
Abstract:Heterocycles of the isoxazolone class stand out in the pharmaceutical field because they have numerous biological properties, such as antioxidant, antifungal and antibacterial properties. Thus, isoxazole derivatives have attracted the attention of organic researchers, and several procedures have been developed to obtain these compounds. The present study aimed to synthesize 17 derivatives of isoxazol-5(4H)-ones using a multicomponent reaction catalyzed by an acidic ionic liquid, which allowed yields from 20-96… Show more
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