Novel Flavanone Naringenin Derivative with Anti-Inflammatory Activity
Rodrigo de Souza,
Lívia Hilgenberg,
Ana Pinto
et al.
Abstract:Naringenin is a flavonoid with several biological activities already reported but with few biological applications in the pharmaceutical field. In this work, a new flavanone, called carboxymidamide (DCHA), synthesized through the condensation reaction between naringenin and aminoguanidine is structurally confirmed through spectroscopic analysis of nuclear magnetic resonance, mass spectrometry and Fourier transform infrared. DCHA was not toxic to human fibroblasts and inhibited macrophage activation in vitro. I… Show more
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