Abstract:To expand the variety of density functionalized compounds evaluated against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), we decided to prepare new acetylated and disubstituted 3-hydroxy bis-oxindoles and isoindigos coupling compounds using known protocols. The corresponding isatin derivatives were synthesized by ZrCl4/EtOH/reflux or HCl/AcOH/ reflux coupling conditions using oxindole and functionalized isatins, furnishing new 3-hydroxy bis‑oxindoles, which were dehydrated into new isoindigos. … Show more
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