One-Class Classification Models for the Authentication of Analgesic Tablet Reference Medicine Using Differential Scanning Calorimetry and Visible-Near Infrared Spectroscopy
Abstract:The aim of this study was to develop a fast, simple and accurate analytical method for the classification of reference tablet analgesic drugs containing dipyrone, orphenadrine and caffeine using differential scanning calorimetry (DSC) and visible-near infrared spectroscopy (VNIRS) associated with one-class chemometric classification algorithm. The training set is based on reference medicine with 15 samples as target class. Three different brands with 10 samples each and five reference medicine samples, obtaini… Show more
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