Synthesis and Biological Evaluation of Novel 1,3-Benzoxathiol-2-one Sulfonamides against Toxic Activities of the Venom of Bothrops jararaca and Bothrops jararacussu Snakes

Chazin, Eliza de Lucas; Martins, Leonardo de Oliveira; Souza, Marcus Vinícius de; Gomes, Cláudia R. B.; Silva, Ana Cláudia da; Branco, Marcelly; Sanchez, Eládio F.; Fuly, André Lopes; Vasconcelos, Thatyana R. A.

doi:10.21577/0103-5053.20210119

Cited by 2 publications

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“…The studies also point out that thiol's compounds, flavonoids, tannins, coumarins, terpenic compounds, alkaloids, and saponins classes also detected in the extract of Petiveria alliacea, are potent modulators of inflammatory damage, and therefore favor the proposal of this study, where the effects of edema in this type of poisoning are neutralized by the extract. This condition opens the possibility to research the use of coadjutants of this and other plants to the use of the antivenom, collaborating in poison damage protection (Sathiyabalan et al, 2017;Mustika et al, 2021;Chazin et al, 2022).…”

Section: Resultsmentioning

confidence: 99%

Antiedematogenic activity of Petiveria alliacea L. in bothropic poisoning

Marcio¹,

Patricia²,

Antônio³

et al. 2022

J. Med. Plants Res.

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The biodiversity of the Brazilian biomes inspires interest in research about the biological activities of the molecules present in the flora. In this line, Petiveria alliacea a common plant species in the savanna of Tocantins, reported in the treatment for snakebites, was studied to analyze the phytochemical profile and evaluate the activity on the edema caused by Bothrops moojeni snake venom. A qualitative phytochemical prospection and a gas chromatography associated with mass spectrometry was performed. Subsequently, it was evaluated whether the extract triggered acute toxicity in Swiss mice (doses of 300 and 2,000 mg/kg), and no toxic effects were observed. Then, the antiedematogenic activity of the extract was performed when administered orally in simulated envenomation with B. moojeni snake venom. The presence of bioactive polyphenolics, flavonoids, tannins, coumarins, terpene, alkaloids and saponins compounds was shown. No toxic effects were observed, and the test extract showed evident antiedematogenic activity. It is understood that the inhibition of edema induced by the venom was obtained by reducing the pathways of the inflammatory cascade. Therefore, the traditional effect associated with the plant has scientific basis, in the same way, that its constituents were qualified and showed no toxic effects and has antiedematogenic activity.

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Section: Resultsmentioning

confidence: 99%

Antiedematogenic activity of Petiveria alliacea L. in bothropic poisoning

Marcio¹,

Patricia²,

Antônio³

et al. 2022

J. Med. Plants Res.

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Study on the synthesis and structure-activity relationship of 1,2,3-triazoles against toxic activities of Bothrops jararaca venom

Souza

Santana

Silva

et al. 2022

Zeitschrift Für Naturforschung C

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Snakebite envenoming is a health concern and has been a neglected tropical disease since 2017, according to the World Health Organization. In this study, we evaluated the ability of ten 1,2,3-triazole derivatives AM001 to AM010 to inhibit pertinent in vitro (coagulant, hemolytic, and proteolytic) and in vivo (hemorrhagic, edematogenic, and lethal) activities of Bothrops jararaca venom. The derivatives were synthesized, and had their molecular structures fully characterized by CHN element analysis, Fourier-transform infrared spectroscopy and Nuclear magnetic resonance. The derivatives were incubated with the B. jararaca venom (incubation protocol) or administered before (prevention protocol) or after (treatment protocol) the injection of B. jararaca venom into the animals. Briefly, the derivatives were able to inhibit the main toxic effects triggered by B. jararaca venom, though with varying efficacies, and they were devoid of toxicity through in vivo, in silico or in vitro analyses. However, it seemed that the derivatives AM006 or AM010 inhibited more efficiently hemorrhage or lethality, respectively. The derivatives were nontoxic. Therefore, the 1,2,3-triazole derivatives may be useful as an adjuvant to more efficiently treat the local toxic effects caused by B. jararaca envenoming.

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Synthesis and Biological Evaluation of Novel 1,3-Benzoxathiol-2-one Sulfonamides against Toxic Activities of the Venom of Bothrops jararaca and Bothrops jararacussu Snakes

Cited by 2 publications

References 0 publications

Antiedematogenic activity of Petiveria alliacea L. in bothropic poisoning

Antiedematogenic activity of Petiveria alliacea L. in bothropic poisoning

Study on the synthesis and structure-activity relationship of 1,2,3-triazoles against toxic activities of Bothrops jararaca venom

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