Bioactive Bioflavonoids from Platonia insignis (Bacuri) Residues as Added Value Compounds

Abstract

Platonia insignis fruit, popularly known as bacuri, is traditionally used in folk medicine for its anti-inflammatory and antioxidant properties. Therefore, this study determined the chemical composition and biological activities of the bacuri’s shell and seeds extracts, considered residues from its consumption and industrial uses. Four biflavonoids (GB-2a, GB-1a, morelloflavone, and volkensiflavone) were identified in the extracts by high-performance liquid chromatography-diode array detection (HPLC-DAD), liquid chromatography tandem mass spectrometry (LC-MS/MS), and liquid chromatography-solid phase extraction-nuclear magnetic resonance (LC-SPE-NMR) techniques. Morelloflavone was identified as the main compound in the shell ethyl acetate extract, being responsible for the high in vitro antioxidant (50% effective concentration (EC50) ranging from 8.0-10.5 µg mL−1 in different protocols), anti-glycant (80%), and moderate inhibition of nitric oxide (1.56 µg mL−1 for > 90% cell viability) activities. This extract showed promising in vivo anti-inflammatory activity evaluated through the paw edema protocol after its incorporation into a liquid-crystalline drug carrier system, reducing the edema by up to 31%. The results demonstrated the potential of the fruit for the development of drugs of natural origin and corroborated to add economic value to these discarded residues.

Bioprospecting as a strategy for conservation and sustainable use of the Brazilian Flora

“…The detection of biflavonoids in Garcinia brasiliensis (Arwa et al 2015), gallic acid derivatives in Spondias tuberosa and Inga laurina (Zeraik et al 2016, Falcoski et al 2021, and anthocyanins in Eugenia jambolana (Dametto et al 2017) with chemopreventive activity indicated a promising potential for their sustainable exploration. In addition, the search for value-added products in fruits residues (inedible parts), led to the detection of biflavonoids in Platonia insignis bark and seeds extracts, including the selective extraction of morelloflavone, which has been reported for several important bioactivities, including chemoprevention (Ribeiro et al 2021).…”

The Platonia insignis Mart. as the Promising Brazilian ‘Amazon Gold’: The State-of-the-Art and Prospects

“…Hypolipidemic Seed Unsaturated fatty acids, xanthones, prenylated benzophenone [39] Legend: (*) Compounds not specified. There is excellent potential for bacuri to develop drugs of natural origin, which have added economic value to the fruit, including the inedible parts of the plant [52]. The antioxidant action observed in studies with different parts of the fruit and palm has been widely cited There is excellent potential for bacuri to develop drugs of natural origin, which have added economic value to the fruit, including the inedible parts of the plant [52].…”

“…There is excellent potential for bacuri to develop drugs of natural origin, which have added economic value to the fruit, including the inedible parts of the plant [52]. The antioxidant action observed in studies with different parts of the fruit and palm has been widely cited There is excellent potential for bacuri to develop drugs of natural origin, which have added economic value to the fruit, including the inedible parts of the plant [52]. The antioxidant action observed in studies with different parts of the fruit and palm has been widely cited in publications dealing with biological effects.…”